Bcl-2 overexpression contributes to laryngeal carcinoma cell survival by forming a complex with Hsp90 beta

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成果类型：

期刊论文

作者：

Li, Sai;Li, Jincheng;Hu, Tian;Zhang, Chuhong;Lv, Xiu;...

通讯作者：

Zuo, Jianhong;Lei, Mingsheng

作者机构：

[Tan, Yixi; Zuo, Jianhong; Lv, Xiu; Wen, Meiling; Li, Sai; Zhang, Chuhong; Yan, Hanxing; Hu, Tian; He, Sha] Univ South China, Affiliated Nanhua Hosp, Dept Oncol, Hengyang 421001, Hunan, Peoples R China.

[Zuo, Jianhong; Li, Sai] Univ South China, Sch Med, 28 Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Li, Jincheng] Shaoyang Univ, Sch Med, Shaoyang 422000, Hunan, Peoples R China.

[Lei, Mingsheng] Peoples Hosp Zhangjiajie City, Dept Resp & Crit Care Med, 192 Gu Yong Rd, Zhangjiajie 427000, Hunan, Peoples R China.

通讯机构：

[Zuo, Jianhong] U

[Lei, Mingsheng] P

Univ South China, Sch Med, 28 Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

Peoples Hosp Zhangjiajie City, Dept Resp & Crit Care Med, 192 Gu Yong Rd, Zhangjiajie 427000, Hunan, Peoples R China.

语种：

英文

关键词：

laryngocarcinoma cancer;Bcl-2;Hsp90 beta

期刊：

ONCOLOGY REPORTS

ISSN：

1021-335X

年：

2017

卷：

期：

页码：

849-856

DOI：

10.3892/or.2016.5295

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81272960]; Science and Technology Department of Hunan Province, China [2013WK2010, 2014SK2015]; Ministry of Human Resources and Social Security of the People's Republic of China [176]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Laryngeal carcinoma (LC) is one of the most common malignant tumors of all head and neck squamous cell carcinomas (HNSCCs). However, the molecular mechanism and genetic basis of the development of LC have not been fully elucidated. To explore the possible mechanism, targeted proteomic analysis was performed on Bcl-2-associated proteins from LC cells. According to our results, 35 proteins associated with Bcl-2 were identified and Hsp90 beta was confirmed by co-immunoprecipitation and western blot analysis. Protein-protein interaction (PPI) analysis indicated that Bcl-2-Hsp90 beta interactions m...

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Bcl-2 overexpression contributes to laryngeal carcinoma cell survival by forming a complex with Hsp90 beta

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