Hydrogen sulfide protects H9c2 cardiac cells against doxorubicin-induced cytotoxicity through the PI3K/Akt/FoxO3a pathway

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期刊论文

作者：

Liu, Mi-Hua*;Zhang, Yuan;He, Jun;Tan, Tian-Ping;Wu, Shao-Jian;...

通讯作者：

Liu, Mi-Hua;Jiang, Zhi-Sheng

作者机构：

[Tan, Tian-Ping; Wu, Shao-Jian; Liu, Mi-Hua; He, Jun] Univ South China, Affiliated Nanhua Hosp, Dept Clin Lab, 336 Dongfeng South Rd, Hengyang 421001, Hunan, Peoples R China.

[Zhang, Yuan] Mawangdui Hosp, Dept Pathol, Changsha 410016, Hunan, Peoples R China.

[Guo, Dong-Ming] Univ South China, Lab Clin Anat, Hengyang 421001, Hunan, Peoples R China.

[Jiang, Zhi-Sheng; Tang, Zhi-Han; Peng, Juan; He, Hui] Univ South China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Liu, Mi-Hua; Jiang, Zhi-Sheng] U

Univ South China, Affiliated Nanhua Hosp, Dept Clin Lab, 336 Dongfeng South Rd, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Apoptosis;Cardiomyocytes;Doxorubicin;FoxO3a;Hydrogen sulphide

期刊：

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

ISSN：

1107-3756

年：

2016

卷：

期：

页码：

1661-1668

DOI：

10.3892/ijmm.2016.2563

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81470435]; Graduate student research innovation project of Hunan province [CX2013B397]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Doxorubicin (DOX) is an efficient drug used in cancer therapy that also produces reactive oxygen species (ROS) that induces severe cytotoxicity, which limits its clinical application. Hydrogen sulfide (H2S), a novel gasotransmitter, has been shown to exert cardioprotective effects. The present study aimed to determine whether exogenous H2S protects H9c2 cardiac cells against DOX-induced cytotoxicity and whether these protective effects are mediated through the PI3K/Akt/FoxO3a pathway. The H9c2 cardiac cells were exposed to 5 microM DOX for 24 h to establish a model of DOX-induced cardiotoxicit...

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Hydrogen sulfide protects H9c2 cardiac cells against doxorubicin-induced cytotoxicity through the PI3K/Akt/FoxO3a pathway

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