Chlamydia trachomatis T3SS Effector CT622 Induces Proinflammatory Cytokines Through TLR2/TLR4-Mediated MAPK/NF-κB Pathways in THP-1 Cells

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Lei, Wenbo;Wen, Yating;Yang, Yewei;Liu, Shuangquan;Li, Zhongyu

通讯作者：

Li, ZY

作者机构：

[Li, Zhongyu; Yang, Yewei; Lei, Wenbo; Wen, Yating] Univ South China, Inst Pathogen Biol, Hengyang Med Sch,Sch Nursing, Hunan Prov Key Lab Special Pathogens Prevent & Co, Hengyang, Peoples R China.

[Liu, Shuangquan; Lei, Wenbo] Univ South China, Affiliated Hosp 1, Inst Microbiol & Infect Dis, Hengyang Med Coll,Dept Clin Lab Med, Hengyang, Peoples R China.

[Li, ZY] Univ South China, Med Coll Hengyang, Inst Pathogen Biol, 28 Changsheng West Rd, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Li, ZY ] U

Univ South China, Med Coll Hengyang, Inst Pathogen Biol, 28 Changsheng West Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Chlamydia trachomatis;CT622;MAPKs;NF-κB;TLRs;inflammation

期刊：

JOURNAL OF INFECTIOUS DISEASES

ISSN：

0022-1899

年：

2023

DOI：

10.1093/infdis/jiad597

基金类别：

National Natural Science Foundation of China [82272383, 32070189, 31900160]; Natural Science Foundation of Hunan Province [2019JJ50554, 2023JJ30540]; Huxiang Youth Talent Support Program of Hunan Province [201RHX002]; Health Commission of Hunan Province [C202304127239]; Clinical Medical Research 4310 Program of the University of South China [20224310NHYCG02]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

护理学院

摘要：

BACKGROUND: The pathogenesis of Chlamydia trachomatis (C. trachomatis) is associated with the induction of the host inflammatory response; however, the precise underlying molecular mechanisms remain poorly understood. METHODS: CT622, a T3SS effector protein, has an important role in the pathogenesis of C. trachomatis; however, little is understood as to whether CT622 can induce a host inflammatory response. Our findings demonstrate that CT622 induces the expression of interleukin-6 (IL-6) and interleukin-8 (IL-8). Mechanistically, these effects...

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Chlamydia trachomatis T3SS Effector CT622 Induces Proinflammatory Cytokines Through TLR2/TLR4-Mediated MAPK/NF-κB Pathways in THP-1 Cells

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