Chlamydia trachomatis pORF5 plasmid-encoded protein regulates autophagy and apoptosis of HeLa cells

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

He, Bei;Zhao, Yuqi;Yang, Xiaoyu;Su, Shengmei;Wen, Yating;...

通讯作者：

Li, Zhongyu;Huang, Qiulin

作者机构：

[He, Bei; Li, Zhongyu; Zhou, Zhou; Zhao, Yuqi; Su, Shengmei; Chen, Hongliang; Wen, Yating; Yang, Xiaoyu] Univ South China, Hengyang Med Coll, Hunan Prov Key Lab Special Pathogens Prevent & Co, Inst Pathogen Biol, Hengyang, Peoples R China.

[Huang, Qiulin] Univ South China, Affiliated Hosp 1, Gastr Canc Res Ctr Hunan Prov, Dept Gen Surg, Hengyang, Peoples R China.

[Li, Zhongyu] Univ South China, Hengyang Med Coll, Inst Pathogen Biol, 28 Changsheng West Rd, Hengyang 421001, Hunan, Peoples R China.

[Huang, Qiulin] Univ South China, Affiliated Hosp 1, Dept Gen Surg, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Li, Zhongyu; Huang, Qiulin] U

Univ South China, Hengyang Med Coll, Inst Pathogen Biol, 28 Changsheng West Rd, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Affiliated Hosp 1, Dept Gen Surg, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

apoptosis;autophagy;Chlamydia trachomatis;crosstalk;pORF5 plasmid protein

期刊：

Biotechnology & Biotechnological Equipment

ISSN：

1310-2818

年：

2019

卷：

期：

页码：

1269-1279

DOI：

10.1080/13102818.2019.1659183

基金类别：

This work was supported by the National Natural Science Foundation of China under grants number 81772210 and 31470277, Construct Program of the Key Discipline in Hunan Province under grant number 2011-76, Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control under grant number 2014-5 and Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study under grant number 2016-429.

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Chlamydia trachomatis is an important human pathogen responsible for a variety of important diseases. pORF5, a plasmid protein in C. trachomatis, has been reported to contribute to chlamydial pathogenesis. Apoptosis and autophagy are two important cellular processes, which also participate in the pathological and the physiological processes in C. trachomatis infection. The present study aimed to explore the effects of pORF5 protein on autophagy and apoptosis in HeLa cells. Stable pORF5-HeLa and vector-HeLa cell lines that were transduced with p...

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Chlamydia trachomatis pORF5 plasmid-encoded protein regulates autophagy and apoptosis of HeLa cells

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