Chlamydia trachomatis plasmid-encoded protein Pgp3 inhibits apoptosis via the PI3K-AKT-mediated MDM2-p53 axis

首页 > 成果 > 详情

认领

导出

下载 Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zou, Yan;Lei, Wenbo;Su, Shengmei;Bu, Jichang;Zhu, Shunxin;...

通讯作者：

Li, Zhongyu;Huang, Qiulin

作者机构：

[Li, Zhongyu; Zou, Yan; Bu, Jichang; Su, Shengmei; Lei, Wenbo] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hunan Prov Key Lab Special Pathogens Prevent & Co, Inst Pathogen Biol,Med Coll, Hengyang 421001, Hunan, Peoples R China.

[Huang, Qiulin] Univ South China, Dept Gen Surg, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.

[Zou, Yan; Zhu, Shunxin] Matern & Child Hlth Care Hosp Xiangtan, Clin Lab, Xiangtan 411100, Hunan, Peoples R China.

通讯机构：

[Li, Zhongyu; Huang, Qiulin] U

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hunan Prov Key Lab Special Pathogens Prevent & Co, Inst Pathogen Biol,Med Coll, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Dept Gen Surg, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Apoptosis;Chlamydia trachomatis;MDM2;PI3K/AKT;Pgp3;p53

期刊：

Molecular and Cellular Biochemistry

ISSN：

0300-8177

年：

2019

卷：

452

期：

1-2

页码：

167-176

DOI：

10.1007/s11010-018-3422-9

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31470277, 81102230]; Construct Program of the Key Discipline in Hunan Province [2011-76]; Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control [2014-5]; Hunan Province Cooperative innovation Center for Molecular Target New Drug Study [2014-405]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Chlamydia trachomatis, the most common human pathogen that causes trachoma and sexually transmitted disease, has developed various strategies for inhibiting host cell apoptosis. Activation of the PI3K (phosphoinositide 3-kinase)/AKT-mediated MDM2 (murine double minute 2)-p53 pathway plays a prominent role in the apoptosis resistance arising from C. trachomatis infection. However, the precise upstream mechanisms by which C. trachomatis activates this pathway have not been adequately investigated. Here, we reveal that the secreted C. trachomatis plasmid-encoded protein Pgp3 inhibits apoptosis in...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Chlamydia trachomatis plasmid-encoded protein Pgp3 inhibits apoptosis via the PI3K-AKT-mediated MDM2-p53 axis

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问