期刊论文

Liu, Yi;Zheng, Xing;Jiang, Zhong-Xing

英文

Medicinal Chemistry Research

1054-2523

2021

30

3

519-534

10.1007/s00044-020-02668-4

The authors thank the Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences (2018-10), the Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (0223-0007-000004), the Undergraduate Research Learning and Innovative Experiment Project (G201910555028, S201910555024, S201910555143, X2019177, X2019178, X2019179, 2018XJXZ349, 2018XJXZ350, 2018XJXZ351, 2018XJXZ360, 2018XJXZ363), Hunan Provincial Hengyang Joint Fund (2020JJ6052), Program for Innovative Talent Team of Hengyang (2017-1), the Key Project of Hengyang Science and Technology Department (2017KJ166) for financial support.

本校为第一且通讯机构

As a disease closely related to the metabolic syndrome, diabetes has become a public health issue that severely affects many people’s quality of life. The search for novel anti-diabetic agents remains the cornerstone to control this challenging disease. Protein tyrosine phosphatase 1B (PTP1B), a negative regulator of insulin and leptin signaling pathways, has turned out to be a potential target of type II diabetes mellitus (T2DM) and obesity. In recent years, the development of novel anti-diabetic drugs based on PTP1B inhibitors has captured t...