期刊论文

Liu, Yi;Zheng, Xing;Jiang, Zhong-Xing

英文

Medicinal Chemistry Research

1054-2523

2021

30

3

519-534

10.1007/s00044-020-02668-4

Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of SciencesChinese Academy of Sciences [2018-10]; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study [0223-0007-000004]; Undergraduate Research Learning and Innovative Experiment Project [G201910555028, S201910555024, S201910555143, X2019177, X2019178, X2019179, 2018XJXZ349, 2018XJXZ350, 2018XJXZ351, 2018XJXZ360, 2018XJXZ363]; Hunan Provincial Hengyang Joint Fund [2020JJ6052]; Program for Innovative Talent Team of Hengyang [2017-1]; Key Project of Hengyang Science and Technology Department [2017KJ166]

本校为第一且通讯机构

As a disease closely related to the metabolic syndrome, diabetes has become a public health issue that severely affects many people’s quality of life. The search for novel anti-diabetic agents remains the cornerstone to control this challenging disease. Protein tyrosine phosphatase 1B (PTP1B), a negative regulator of insulin and leptin signaling pathways, has turned out to be a potential target of type II diabetes mellitus (T2DM) and obesity. In recent years, the development of novel anti-diabetic drugs based on PTP1B inhibitors has captured t...