Curcumin-Nicotinate Attenuates Hippocampal Synaptogenesis Dysfunction in Hyperlipidemia Rats by the BDNF/TrkB/CREB Pathway: Involving Idol/LDLR Signaling to Eliminate Aβ Deposition

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wang, Lin-Yu;Liu, Jiao;Peng, Yi-Zhu;Zhang, Cai-Ping;Zou, Wei;...

通讯作者：

Zhang, P

作者机构：

[Zou, Wei; Wang, Lin-Yu; Zhang, Ping] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Neurol, Hengyang, Peoples R China.

[Zhan, Ke-Bin; Peng, Yi-Zhu; Liu, Jiao; Liu, Feng] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Neurol, Hengyang, Peoples R China.

[Zhang, Cai-Ping] Univ South China, Hengyang Med Sch, Dept Biochem, Hengyang, Peoples R China.

[Zhang, Ping] Univ South China, Affiliated Nanhua Hosp, Dept Neurol, 336 S Dongfeng Rd, Hengyang 421002, Hunan, Peoples R China.

通讯机构：

[Zhang, P ] U

Univ South China, Affiliated Nanhua Hosp, Dept Neurol, 336 S Dongfeng Rd, Hengyang 421002, Hunan, Peoples R China.

语种：

英文

关键词：

hyperlipidemia;high-fat diet;Curcumin-Nicotinate;amyloid-beta;BDNF/TrkB/CREB signaling;synaptogenesis;Idol/LDLR pathway

期刊：

Natural Product Communications

ISSN：

1934-578X

年：

2022

卷：

期：

DOI：

10.1177/1934578X221141162

基金类别：

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Natural Science Foundation of Hunan Province, Clinical Medical Technology Innovation Guidance Project of Hunan Province (grant number 2020JJ4553, 2020SK51908).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Hyperlipidemia has been demonstrated to evoke Alzheimer disease (AD) pathologies such as Amyloid-beta (A beta) deposition and synaptogenesis dysfunction in the hippocampus. Curcumin gives protection against anti-amyloid properties and synaptogenesis dysfunction. Curcumin-Nicotinate (CurTn), a new type of curcumin derivative, ameliorates cognitive impairment by rescuing autophagic flux in the CA1 hippocampus of diabetic rats. However, whether Curtn possesses an antagonistic effect on AD-related pathologies in the hippocampus induced by hyperlipidemia remains ill-defined. The present study aims ...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Curcumin-Nicotinate Attenuates Hippocampal Synaptogenesis Dysfunction in Hyperlipidemia Rats by the BDNF/TrkB/CREB Pathway: Involving Idol/LDLR Signaling to Eliminate Aβ Deposition

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问