Curcumin-Nicotinate Attenuates Hippocampal Synaptogenesis Dysfunction in Hyperlipidemia Rats by the BDNF/TrkB/CREB Pathway: Involving Idol/LDLR Signaling to Eliminate Aβ Deposition

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成果类型：

期刊论文

作者：

Wang, Lin-Yu;Liu, Jiao;Peng, Yi-Zhu;Zhang, Cai-Ping;Zou, Wei;...

通讯作者：

Zhang, P

作者机构：

[Zou, Wei; Wang, Lin-Yu; Zhang, Ping] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Neurol, Hengyang, Peoples R China.

[Zhan, Ke-Bin; Peng, Yi-Zhu; Liu, Jiao; Liu, Feng] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Neurol, Hengyang, Peoples R China.

[Zhang, Cai-Ping] Univ South China, Hengyang Med Sch, Dept Biochem, Hengyang, Peoples R China.

[Zhang, Ping] Univ South China, Affiliated Nanhua Hosp, Dept Neurol, 336 S Dongfeng Rd, Hengyang 421002, Hunan, Peoples R China.

通讯机构：

[Zhang, P ] U

Univ South China, Affiliated Nanhua Hosp, Dept Neurol, 336 S Dongfeng Rd, Hengyang 421002, Hunan, Peoples R China.

语种：

英文

关键词：

amyloid beta protein;amyloid beta protein[1-40];amyloid beta protein[1-42];brain derived neurotrophic factor;curcumin;curcumin plus nicotinate;cyclic AMP responsive element binding protein;disks large homolog 4;glutamate receptor 1;indoleamine 2,3 dioxygenase;indoleamine 2,3 dioxygenase 1;low density lipoprotein receptor;neuroprotective agent;nicotinic acid derivative;synapsin I;unclassified drug;Alzheimer disease;animal experiment;animal model;animal tissue;antagonistic effect;Article;controlled study;drug mechanism;drug megadose;drug potency;enzyme activity;hippocampus;hyperlipidemia;lipid diet;low drug dose;male;molecular biology;neuroprotection;nonhuman;protein expression level;rat;signal transduction;synapse;synaptogenesis;upregulation

期刊：

Natural Product Communications

ISSN：

1934-578X

年：

2022

卷：

期：

页码：

1934578X2211411

DOI：

10.1177/1934578X221141162

基金类别：

The authors thank Professor Duan-Fang Liao of the Hunan University of Chinese Medicine for proving Curcumin-Nicotinate. The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Natural Science Foundation of Hunan Province, Clinical Medical Technology Innovation Guidance Project of Hunan Province (grant number 2020JJ4553, 2020SK51908). The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Natural Science Foundation of Hunan Province, Clinical Medical Technology Innovation Guidance Project of Hunan Province (grant number 2020JJ4553, 2020SK51908).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Hyperlipidemia has been demonstrated to evoke Alzheimer disease (AD) pathologies such as Amyloid-β (Aβ) deposition and synaptogenesis dysfunction in the hippocampus. Curcumin gives protection against anti-amyloid properties and synaptogenesis dysfunction. Curcumin-Nicotinate (CurTn), a new type of curcumin derivative, ameliorates cognitive impairment by rescuing autophagic flux in the CA1 hippocampus of diabetic rats. However, whether Curtn possesses an antagonistic effect on AD-related pathologies in the hippocampus induced by hyperlipidemia...

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Curcumin-Nicotinate Attenuates Hippocampal Synaptogenesis Dysfunction in Hyperlipidemia Rats by the BDNF/TrkB/CREB Pathway: Involving Idol/LDLR Signaling to Eliminate Aβ Deposition

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