CircRNAs: A new perspective of biomarkers in the nervous system

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成果类型：

期刊论文

作者：

Ma, Yun;Liu, Yixuan;Jiang, Zhisheng*

通讯作者：

Jiang, Zhisheng

作者机构：

[Liu, Yixuan; Jiang, Zhisheng; Ma, Yun] Univ South China, Hunan Int Sci & Technol Cooperat Base Arterioscle, Key Lab Arteriosclerol Hunan Prov, Inst Cardiovasc Dis,Hengyang Med Sch, Hengyang 421001, Peoples R China.

[Liu, Yixuan; Ma, Yun] Univ South China, Inst Biochem & Mol Biol, Hengyang 421001, Peoples R China.

[Ma, Yun] Dept Educ, Key Lab Ecol Environm & Crit Human Dis Prevent Hu, Hengyang 421001, Peoples R China.

[Ma, Yun] Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

[Jiang, Zhisheng] Univ South China, Hengyang Med Sch, Hengyang 421001, Peoples R China.

通讯机构：

[Jiang, Zhisheng] U

Univ South China, Hengyang Med Sch, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

Circular RNAs;MicroRNA sponge;Nervous system diseases;Biomarker

期刊：

Biomedicine & Pharmacotherapy

ISSN：

0753-3322

年：

2020

卷：

128

页码：

110251

DOI：

10.1016/j.biopha.2020.110251

基金类别：

This work was supported by the National Natural Science Foundation of China ( 81200881 , 81971087 to MY, 81670429 , 81470435 to ZSJ), the National Key Research and Development Project （ 2019YFA0801601 ） and the Hunan Provincial Innovation Foundation for Postgraduate ( CX2018B624 ).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Circular RNAs (circRNAs) are a class of newly-identified non-coding RNA that lack 5’ (cap) and 3’ (polyadenylation) ends and are linked by a covalent bond to form a closed loop structure. In comparison to linear RNAs, circRNAs are more resistant to exonuclease RNase R-mediated degradation with a much stronger stability due to the absence of 3’ terminals. Consequently, the extraordinary nature of circRNAs enables it to be potentially used as a biomarker and gene targeting. Similarly, circRNAs can play a significant regulatory role in gene exp...

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