Quinic acid regulated TMA/TMAO-related lipid metabolism and vascular endothelial function through gut microbiota to inhibit atherosclerotic

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成果类型：

期刊论文

作者：

Jin, Qiao;Zhang, Chiyuan;Chen, Ran;Jiang, Luping;Li, Hongli;...

通讯作者：

Wu, Pengcui;Li, L

作者机构：

[Chen, Ran; Li, Liang; Jin, Qiao; Jiang, Luping; Wu, Pengcui; Wu, PC] Univ South China, Changsha Cent Affiliated Hosp, Hengyang Med Sch, Dept Cardiovasc Med, Changsha 410004, Hunan, Peoples R China.

[Jin, Qiao] Cent South Univ, Xiangya Hosp 3, Dept Cardiovasc Med, Changsha 410013, Hunan, Peoples R China.

[Zhang, Chiyuan] Cent South Univ, Xiangya Hosp, Dept Cardiovasc Med, Changsha, Hunan, Peoples R China.

[Li, Hongli] Cent South Univ, Xiangya Hosp, Dept Hematol, Changsha 410000, Hunan, Peoples R China.

通讯机构：

[Li, L ; Wu, PC] U

Univ South China, Changsha Cent Affiliated Hosp, Hengyang Med Sch, Dept Cardiovasc Med, Changsha 410004, Hunan, Peoples R China.

语种：

英文

关键词：

Quinic acid;TMAO;Gut microbiota;Metabolism;Atherosclerosis

期刊：

Journal of Translational Medicine

ISSN：

1479-5876

年：

2024

卷：

期：

页码：

1-20

DOI：

10.1186/s12967-024-05120-y

基金类别：

This work was supported by the Natural Science Foundation of Hunan Province (No. 2022JJ30631 and No. 2023JJ60072), and the Changsha Municipal Health and Wellness Committee Fund (No. KJ-A2023001).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Background: Quinic acid (QA) and its derivatives have good lipid-lowering and hepatoprotective functions, but their role in atherosclerosis remains unknown. This study attempted to investigate the mechanism of QA on atherogenesis in Apoe−/− mice induced by HFD. Methods: HE staining and oil red O staining were used to observe the pathology. The PCSK9, Mac-3 and SM22a expressions were detected by IHC. Cholesterol, HMGB1, TIMP-1 and CXCL13 levels were measured by biochemical and ELISA. Lipid metabolism and the HMGB1-SREBP2-SR-BI pathway were det...

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Quinic acid regulated TMA/TMAO-related lipid metabolism and vascular endothelial function through gut microbiota to inhibit atherosclerotic

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