Deciphering low-dose radiation-induced cytotoxic effects:The application of integrative transcriptomics and metabolomics analysis in lung organoid-based 3D in vitro model

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成果类型：

期刊论文

作者：

Xuan, Lihui;Luo, Jinhua;Pan, Huiji;Xie, Dafei;Huang, Xin;...

通讯作者：

Huang, RX;Bai, Chenjun;Guan, Hua;Zhou, PK

作者机构：

[Luo, Jinhua; Xuan, Lihui; Huang, RX; Pan, Huiji; Huang, Ruixue] Cent South Univ, Xiangya Sch Publ Hlth, Dept Occupat & Environm Hlth, Changsha 82230108, Hunan, Peoples R China.

[Zhou, Ping-Kun; Xie, Dafei; Han, Yang; Bai, Chenjun; Huang, Xin; Guan, Hua; Bai, CJ] Beijing Inst Radiat Med, Dept Radiat Biol, Beijing Key Lab Radiobiol, Beijing 100850, Peoples R China.

[Han, Yang; Zhou, Ping-Kun] Univ South China, Hengyang Med Coll, Sch Publ Hlth, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Guan, H; Zhou, PK ; Bai, CJ] B

[Huang, RX ] C

Cent South Univ, Xiangya Sch Publ Hlth, Dept Occupat & Environm Hlth, Changsha 82230108, Hunan, Peoples R China.

Beijing Inst Radiat Med, Dept Radiat Biol, Beijing Key Lab Radiobiol, Beijing 100850, Peoples R China.

语种：

英文

关键词：

Low-dose radiation;Lung organoids;Transcriptomics;Metabolomics

期刊：

Ecotoxicology and Environmental Safety

ISSN：

0147-6513

年：

2025

卷：

302

页码：

118530

DOI：

10.1016/j.ecoenv.2025.118530

机构署名：

本校为其他机构

院系归属：

公共卫生学院

摘要：

Although the adverse effects induced by acute high-dose radiation from nuclear accidents have been intensively explored, the biological effects of low-dose radiation remain unclear. This study aimed to identify the role of low-dose radiation in three-dimensional (3D) lung organoids using transcriptomic and metabolomic analyses. An irradiation dose of 0 01 Gy was utilized to simulate environmental radiation exposure. Lung organoids were included in the study. Through metabolomic analysis, compared to the control, 290, 284, and 492 metabolites w...

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Deciphering low-dose radiation-induced cytotoxic effects:The application of integrative transcriptomics and metabolomics analysis in lung organoid-based 3D in vitro model

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