Anti-Inflammatory and Immune Regulatory Actions of Naja naja atra Venom

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成果类型：

期刊论文

作者：

Wang, Shu-Zhi;Qin, Zheng-Hong*

通讯作者：

Qin, Zheng-Hong

作者机构：

[Wang, Shu-Zhi] Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.

[Wang, Shu-Zhi] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

[Qin, Zheng-Hong] Soochow Univ, Coll Pharmaceut Sci, Dept Pharmacol, Suzhou 215123, Peoples R China.

[Qin, Zheng-Hong] Soochow Univ, Jiangsu Key Lab Translat Res & Therapy Neuropsych, Jiangsu Key Lab Prevent & Translat Med Geriatr Di, Lab Aging & Nervous Dis,Coll Pharmaceut Sci, Suzhou 215123, Peoples R China.

通讯机构：

[Qin, Zheng-Hong] S

Soochow Univ, Coll Pharmaceut Sci, Dept Pharmacol, Suzhou 215123, Peoples R China.

Soochow Univ, Jiangsu Key Lab Translat Res & Therapy Neuropsych, Jiangsu Key Lab Prevent & Translat Med Geriatr Di, Lab Aging & Nervous Dis,Coll Pharmaceut Sci, Suzhou 215123, Peoples R China.

语种：

英文

关键词：

*NF-kappaB;*T lymphocytes;*allograft rejection;*anti-inflammation;*cobra venom;*complement system;*immune regulation;*nephritis;*pneumonia;*rheumatoid arthritis;*systemic lupus erythematosus

期刊：

TOXINS

ISSN：

2072-6651

年：

2018

卷：

期：

DOI：

10.3390/toxins10030100

基金类别：

South China University Research Fund [2016XQD45]; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, China

机构署名：

本校为第一机构

院系归属：

药学与生物科学学院

摘要：

Naja naja atra venom (NNAV) is composed of various proteins, peptides, and enzymes with different biological and pharmacological functions. A number of previous studies have reported that NNAV exerts potent analgesic effects on various animal models of pain. The clinical studies using whole venom or active components have confirmed that NNAV is an effective and safe medicine for treatment of chronic pain. Furthermore, recent studies have demonstrated that NNAV has anti-inflammatory and immune regulatory actions in vitro and in vivo. In this rev...

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