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Deciphering the impact of MreB on the morphology and pathogenicity of the aquatic pathogen Spiroplasma eriocheiris.

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成果类型:
期刊论文
作者:
Li, Rong;Cao, Xiaohui;Chen, Jiaxin;He, Tingting;Zhang, Yan;...
作者机构:
[Li, Rong; Chen, Jiaxin; Xie, Mengji; Zhang, Siyuan; Shi, Kailin; Wang, Yifei; Qiu, Yanyan; Zhang, Yan; Xu, Yuhua; Wang, Yaqi] Institute of Pathogenic Biology, Basic Medical School,University of South China, Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, Hengyang, Hunan, 421001, China
[Cao, Xiaohui] Jiangsu Marine Fisheries Research Institute, Nantong, Jiangsu, 226007, China
[He, Tingting] Shaoxing Center for Disease Control and Prevention, 276 Century Street, Shaoxing, Zhejiang Province, 312000, China
[Wang, Wen] Jiangsu Key Laboratory for Biodiversity and Biotechnology, Jiangsu Key Laboratory for Aquatic Crustacean Diseases, College of Life Sciences, Nanjing Normal University, Jiangsu, China
[Liu, Peng] Institute of Pathogenic Biology, Basic Medical School,University of South China, Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, Hengyang, Hunan, 421001, China. pengliu@live.cn
语种:
英文
关键词:
Spiroplasma eriocheiris;A22;MreB;Pathogenicity and morphology;Phalloidin
期刊:
Biology Direct
ISSN:
1745-6150
年:
2024
卷:
19
期:
1
页码:
98
机构署名:
本校为第一机构
院系归属:
医学院
摘要:
BACKGROUND: Spiroplasma eriocheiris has been proved to be a pathogen causing tremor disease of Eriocheir sinensis, it is also infectious to other aquatic crustaceans, resulting in a serious threat on the sustainable development of the aquaculture industry. S. eriocheiris is a helical-shaped microbe without a cell wall, and its motility is related to the cytoskeleton protein MreB which belongs to the actin superfamily and has five MreB homologs. RESULTS: In this study, we purified MreB3, MreB4 and MreB5, and successfully prepared monoclonal antibodies. After S. eriocheiris treated with actin st...

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