期刊论文

He, He;Song, ZY

英文

Nature Communications

2041-1723

2023

14

1

4105

10.1038/s41467-023-39811-9

National Natural Science Foundation of China [31970711, 32125011, 91854107]; Ministry of Science and Technology of the People's Republic of China [2018YFA0800700]; Fundamental Research Funds for the Central Universities

本校为其他机构

Mitochondria are the key organelles for sensing oxygen, which is consumed by oxidative phosphorylation to generate ATP. Lysosomes contain hydrolytic enzymes that degrade misfolded proteins and damaged organelles to maintain cellular homeostasis. Mitochondria physically and functionally interact with lysosomes to regulate cellular metabolism. However, the mode and biological functions of mitochondria-lysosome communication remain largely unknown. Here, we show that hypoxia remodels normal tubular mitochondria into megamitochondria by inducing broad inter-mitochondria contacts and subsequent fus...