期刊论文

中文

中国工业医学杂志

1002-221X

2000

13

4

210-211

10.3969/j.issn.1002-221X.2000.04.006

衡阳市科委资助!项目 （项目号 970 0 0 3）；

本校为第一机构

目的　探讨尿N 乙酰 β D 氨基葡萄糖苷酶 （NAG）对铅毒性肾损害早期诊断的临床意义。 方法　采用对 硝基苯酚比色法对 85名铅作业工人尿NAG活性进行测定。结果　铅作业工人尿NAG活性、尿蛋白及尿 β2 MG均显著增高。随着肾损害程度的加重 ,尿NAG活性亦随之显著增加 ,并与尿蛋白、尿 β2 MG呈显著性正相关。在铅性肾损害早期 ,尿NAG活性可先于尿蛋白、尿 β2 MG出现异常。结论　长期职业性铅接触可造成肾功能损害 ,而尿NAG可作为铅性肾损害的早期灵敏的监测指标。

Objective To study the determination for the activity of urine N-acetyl-β-D-glucosaminidase (NAG)in early diagnosis for renal damage caused by lead.Methods The activity of urine NAG was determined by colorimetry with para-nitrophenol in 85 workers exposed to lead.Results The activity of NAG,protein excretion and β 2-microglobulin(β 2-MG)in their urine increased significantly,as compared to those of controls.The activity of urine NAG increased significantly with severity of renal damage and correlated positively with levels of urine protein a...