期刊论文

Feng, Jianbo;Zu, XY

英文

Oncogene

0950-9232

2023

42

44

3236-3251

10.1038/s41388-023-02823-2

Funding This work was supported by grants from the National Natural Science Foundation of China (No. 82103171, Jianbo Feng) and the Natural Science Foundation of Hunan Province (No. 2021JJ30612, Jianbo Feng; 2020JJ4551, Xuyu Zu), and the Clinical Medical Research “4310” Program of the University of South China (20224310NHYCG07).

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Breast cancer (BC) is the most commonly diagnosed cancer and the leading cause of cancer-related death among females. Metastasis accounts for the majority of BC related deaths. One feasible strategy to solve this challenging problem is to disrupt the capabilities required for tumor metastasis. Herein, we verified a novel metastasis suppressive circRNA, circPOKE in BC. circPOKE was downregulated in primary and metastatic BC tissues and overexpression of circPOKE inhibited the metastatic potential but not the proliferative ability of BC cells in vitro and in vivo. Mechanistically, circPOKE compe...