TET2: A novel epigenetic regulator and potential intervention target for atherosclerosis

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成果类型：

期刊论文

作者：

Liu, Yami;Peng, Wen;Qu, Kai;Lin, Xiaolong;Zeng, Zhaolin;...

通讯作者：

Wang, Zuo

作者机构：

[Chen, Jiaojiao; Liu, Yami; Zeng, Zhaolin; Wang, Zuo; Wei, Dangheng] Univ South China, Inst Cardiovasc Dis, Key Lab Atherosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.

[Peng, Wen] Univ South China, Affiliated Hosp 1, Dept Spine Surg, Hengyang, Hunan, Peoples R China.

[Qu, Kai] Chongqing Univ, Coll Bioengn, Chongqing, Peoples R China.

[Lin, Xiaolong] Third Peoples Hosp Huizhou, Dept Pathol, Huizhou, Peoples R China.

通讯机构：

[Wang, Zuo] U

Univ South China, Inst Cardiovasc Dis, Key Lab Atherosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

TET2;DNA demethylation;atherosclerosis;inflammation

期刊：

DNA AND CELL BIOLOGY

ISSN：

1044-5498

年：

2018

卷：

期：

页码：

517-523

DOI：

10.1089/dna.2017.4118

基金类别：

Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81070221]; Innovative Research Team for Science and Technology in Higher Educational Institutions of Hunan Province; Construct Program of the Key Discipline in Hunan Province

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Atherosclerosis is the underlying cause of cardio-cerebrovascular disease. However, the mechanisms of atherosclerosis are still unclear. The modification of DNA methylation has an important role in atherosclerosis development. As a member of the Ten-eleven translocation (TET) family, TET methylcytosine dioxygenase 2 (TET2) can modify DNA methylation by catalyzing 5-methylcytosine to 5-hydroxymethylcytosine and mediate DNA demethylation. Recent findings suggest that TET2 is related to the phenotype transformation of vascular smooth muscle cells, endothelial dysfunction, and inflammation of macr...

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TET2: A novel epigenetic regulator and potential intervention target for atherosclerosis

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