期刊论文

Tang, Huifang;Yin, Kai

英文

Journal of Cardiovascular Translational Research

1937-5387

2020

13

1

110-119

10.1007/s12265-019-09891-4

This research was supported by the National Natural Sciences Foundation of China (81470569), The Innovation Foundation for Postgraduate of Hunan Province (CX2017B550, CX2016B490), Natural Science Foundation of Hunan Province, China (2018JJ2341), Science Foundation of The Heath and Family Planning Commission in Hunan Province of China (B2019122), and the National College Students Innovation and Entrepreneurship Fund (201710555015, 201710555010).

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Despite primary percutaneous coronary intervention (PPCI) and the availability of optimal medications, including dual antiplatelet therapy (DAPT), most patients still experience major adverse cardiovascular events (MACEs) due to frequent recurrence of thrombotic complications and myocardial infarction (MI). MI occurs secondary to a massive loss of endothelial cells (ECs), vascular smooth muscle cells (VSMCs), and cardiomyocytes (CMs). The adult cardiovascular system gradually loses the ability to spontaneously and regularly regenerate ECs, VSMC...