Multifaceted functions of RPS27a: An unconventional ribosomal protein

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成果类型：

期刊论文

作者：

Luo, Jingshun;Zhao, Hong;Chen, Linxi;Liu, Meiqing

通讯作者：

Linxi Chen<&wdkj&>Meiqing Liu<&wdkj&>Linxi Chen Linxi Chen Linxi Chen<&wdkj&>Meiqing Liu Meiqing Liu Meiqing Liu

作者机构：

[Luo, Jingshun; Liu, Meiqing] Kunming Med Univ, Key Lab Cardiovasc Dis Yunnan Prov, Key Lab Tumor Immunol Prevent & Treatment Yunnan P, Cent Lab Yanan Hosp, Kunming, Yunnan, Peoples R China.

[Luo, Jingshun; Zhao, Hong; Chen, Linxi] Univ South China, Hunan Prov Key Lab Tumor Microenvironm Respons Dru, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang Med Sch,Inst Pharm & Pharmacol, Hengyang, Hunan, Peoples R China.

[Zhao, Hong] Univ South China, Nursing Coll, Hengyang Med Sch, Hengyang, Hunan, Peoples R China.

[Chen, Linxi] Univ South China, Hunan Prov Key Lab Tumor Microenvironm Respons Dru, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang Med Sch,Inst Pharm & Pharmacol, Hengyang 421001, Hunan, Peoples R China.

[Liu, Meiqing] Kunming Med Univ, Key Lab Cardiovasc Dis Yunnan Prov, Key Lab Tumor Immunol Prevent & Treatment Yunnan P, Cent Lab Yanan Hosp, Kunming 650000, Yunnan, Peoples R China.

通讯机构：

[Linxi Chen; Linxi Chen Linxi Chen Linxi Chen] I

[Meiqing Liu; Meiqing Liu Meiqing Liu Meiqing Liu] K

Key Laboratory of Cardiovascular Diseases of Yunnan Province, Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Central laboratory of Yan'an Hospital Affiliated to Kunming Medical University, Kunming, Yunnan, China<&wdkj&>Institute of Pharmacy and Pharmacology, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang Medical School, University of South China, Hengyang, Hunan, China

语种：

英文

关键词：

cancer;mercury;plant;ribosomal protein S27a;ubiquitin

期刊：

JOURNAL OF CELLULAR PHYSIOLOGY

ISSN：

0021-9541

年：

2023

卷：

238

期：

页码：

485-497

DOI：

10.1002/jcp.30941

基金类别：

National Natural Science Foundation of China; Hunan Provincial Natural Science Foundation; Postgraduate Scientific Research Innovation Project of Hunan Province; [81903615]; [2021JJ30606]; [CX20221029]

机构署名：

本校为其他机构

院系归属：

药学与生物科学学院

摘要：

The ribosomal protein S27a (RPS27a) is cleaved from the fusion protein ubiquitin–RPS27a (Ub–RPS27a). Generally, Ub and RPS27a are coexpressed as a fusion protein but function independently after Ub is cleaved from RPS27a by a deubiquitinating enzyme. We reviewed the functions of RPS27 in various cancers, including colorectal cancer, liver cancer, chronic myeloid leukemia, and renal carcinoma. We also introduced a mechanism through which RPS27a affects the physiological processes in animals and plants. Abstract The ribosomal protein S27a (RPS2...

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Multifaceted functions of RPS27a: An unconventional ribosomal protein

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