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Multifaceted functions of RPS27a: An unconventional ribosomal protein

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成果类型:
期刊论文
作者:
Luo, Jingshun;Zhao, Hong;Chen, Linxi;Liu, Meiqing
通讯作者:
Linxi Chen<&wdkj&>Meiqing Liu<&wdkj&>Linxi Chen Linxi Chen Linxi Chen<&wdkj&>Meiqing Liu Meiqing Liu Meiqing Liu
作者机构:
[Luo, Jingshun; Liu, Meiqing] Kunming Med Univ, Key Lab Cardiovasc Dis Yunnan Prov, Key Lab Tumor Immunol Prevent & Treatment Yunnan P, Cent Lab Yanan Hosp, Kunming, Yunnan, Peoples R China.
[Luo, Jingshun; Zhao, Hong; Chen, Linxi] Univ South China, Hunan Prov Key Lab Tumor Microenvironm Respons Dru, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang Med Sch,Inst Pharm & Pharmacol, Hengyang, Hunan, Peoples R China.
[Zhao, Hong] Univ South China, Nursing Coll, Hengyang Med Sch, Hengyang, Hunan, Peoples R China.
[Chen, Linxi] Univ South China, Hunan Prov Key Lab Tumor Microenvironm Respons Dru, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang Med Sch,Inst Pharm & Pharmacol, Hengyang 421001, Hunan, Peoples R China.
[Liu, Meiqing] Kunming Med Univ, Key Lab Cardiovasc Dis Yunnan Prov, Key Lab Tumor Immunol Prevent & Treatment Yunnan P, Cent Lab Yanan Hosp, Kunming 650000, Yunnan, Peoples R China.
通讯机构:
[Linxi Chen; Linxi Chen Linxi Chen Linxi Chen] I
[Meiqing Liu; Meiqing Liu Meiqing Liu Meiqing Liu] K
Key Laboratory of Cardiovascular Diseases of Yunnan Province, Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Central laboratory of Yan'an Hospital Affiliated to Kunming Medical University, Kunming, Yunnan, China<&wdkj&>Institute of Pharmacy and Pharmacology, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang Medical School, University of South China, Hengyang, Hunan, China
语种:
英文
关键词:
biological marker;mouse double minute 2 homolog;protein p53;ribosomal protein s27a;ribosome protein;unclassified drug;ribosomal protein S27a;ribosome protein;RPS27a protein, human;ubiquitin;animal;carcinogenesis;chemical structure;chronic myeloid leukemia;colorectal cancer;human;kidney carcinoma;liver cancer;nonhuman;pathophysiology;plant;protein analysis;protein function;protein structure;Review;genetics;liver tumor;male;metabolism;mouse;spermatozoon motility;Animals;Humans;Liver Neoplasms;Male;Mice;Ribosomal Proteins;Sperm Motility;Ubiquitin;Ubiquitins
期刊:
JOURNAL OF CELLULAR PHYSIOLOGY
ISSN:
0021-9541
年:
2023
卷:
238
期:
3
页码:
485-497
基金类别:
The study was supported by Grants from the National Natural Science Foundation of China (81903615), Hunan Provincial Natural Science Foundation (2021JJ30606), and the Postgraduate Scientific Research Innovation Project of Hunan Province (CX20221029).
机构署名:
本校为其他机构
院系归属:
药学与生物科学学院
摘要:
The ribosomal protein S27a (RPS27a) is cleaved from the fusion protein ubiquitin–RPS27a (Ub–RPS27a). Generally, Ub and RPS27a are coexpressed as a fusion protein but function independently after Ub is cleaved from RPS27a by a deubiquitinating enzyme. As an RP, RPS27a assembles into ribosomes, but it also functions independently of ribosomes. RPS27a is involved in the development and poor prognosis of various cancers, such as colorectal cancer, liver cancer, chronic myeloid leukemia, and renal carcinoma, and is associated with poor prognosis. ...

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