ROS-Autophagy pathway mediates monocytes-human umbilical vein endothelial cells adhesion induced by apelin-13

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成果类型：

期刊论文

作者：

Liu, Meiqing;Li, Hening;Zhou, Qun;Zhao, Hong;Lv, Deguan;...

通讯作者：

Chen, Zhe;Li, Lanfang;Chen, Linxi

作者机构：

[Huang, Shifang; Lv, Deguan; Jiang, Jinyong; Tang, Mingzhu; Wu, Di; Liu, Meiqing; Zhao, Hong; Hu, Haoliang; Chen, Zhe; Li, Lanfang; Chen, Linxi; Liu, Jiaqi; Li, Hening; He, Lu; Zhou, Qun; Cao, Jiangang; Wu, Lele] Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.

[Liu, Meiqing] Second Peoples Hosp Yunnan Prov, Dept Pharm, Kunming, Yunnan, Peoples R China.

[Li, Hening] First Peoples Hosp Yueyang, Dept Pharm, Yueyang, Hunan, Peoples R China.

[Zhou, Qun] Hunan Univ Med, Coll Pharm, Huaihua, Peoples R China.

通讯机构：

[Chen, Z; Li, LF; Chen, LX] U

Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

apelin-13;autophagy;cell adhesion;NOX;ROS

期刊：

JOURNAL OF CELLULAR PHYSIOLOGY

ISSN：

0021-9541

年：

2018

卷：

233

期：

页码：

6839-6850

DOI：

10.1002/jcp.26554

基金类别：

Construct Program of the Key Discipline in Human Province; Hunan Province Cooperative Innovation Center for Molecular Target New Drugs Study [2014405]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81503074, 81270420, 81470434, 81670265]; Hunan Province Cooperative Innovation Center for Molecular Target New Drugs Study; Hunan Provincial Education DepartmentHunan Provincial Education Department [2014405]

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

Apelin is the endogenous ligand of APJ receptor. Both monocytes (MCs) and human umbilical vein endothelial cells (HUVECs) express apelin and APJ, which play important roles in the physiological processes of atherosclerosis. Our previous research indicated that apelin-13 promoted MCs-HUVECs adhesion. Here, we further explore the mechanism responsible for MCs-HUVECs adhesion induced by apelin-13. Apelin-13 promoted reactive oxygen species (ROS) generation and NOX4 expression in HUVECs. Apelin-13 inducedautophagy, increased proteins beclin1 and LC...

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ROS-Autophagy pathway mediates monocytes-human umbilical vein endothelial cells adhesion induced by apelin-13

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