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H2S inhibits apo(a) expression and secretion through PKCα/FXR and Akt/HNF4α pathways in HepG2 cells

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成果类型:
期刊论文
作者:
Qu, Kai;Liu, Ya-mi;He, Xing-lan;Zhang, Hai;Zhang, Kai;...
通讯作者:
Wang, Zuo
作者机构:
[Qu, Kai; Lei, Jian-jun; Tang, Ya-ling; Yu, Xiao-hua; Peng, Juan; Wei, Dang-heng; Liu, Ya-mi; He, Xing-lan; Zhang, Hai; Wang, Zuo; Zhang, Kai] Univ South China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.
[Zeng, Jun-fa; Zhang, Kai] Univ South China, Hosp 2, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Wang, Zuo] U
Univ South China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
apolipoprotein(a);farnesoid X receptor;hepG2 cell;hepatocyte nuclear factor 4alpha;hydrogen sulfide;lipoprotein (a)
期刊:
Cell Biology International
ISSN:
1065-6995
年:
2016
卷:
40
期:
8
页码:
906-916
基金类别:
Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81070221]; Innovative Research Team for Science and Technology in Higher Educational Institutions of Hunan Province; Construct Program of the Key Discipline in Hunan Province
机构署名:
本校为第一且通讯机构
院系归属:
医学院
药学与生物科学学院
摘要:
Lipoprotein(a) [Lp(a)] is a strong genetic risk factor for coronary heart diseases. However, the metabolism of this protein remains poorly understood. Efficient and specific drugs that can decrease high plasma levels of Lp(a) have not been developed yet. Hydrogen sulfide (H2S), a member of the gas transmitter family, performs important biological actions, including protection against cardiovascular diseases and maintenance of the lipid metabolism equilibrium in hepatocytes and adipocytes. In this study, we investigated the possible molecular me...

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