Genome-wide identification of DNA-PKcs-associated RNAs by RIP-Seq

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成果类型：

期刊论文

作者：

Song, Zhiquan;Xie, Ying;Guo, Zongpei;Han, Yang;Guan, Hua;...

通讯作者：

Ma, Teng;Zhou, Ping-kun

作者机构：

[Zhou, Ping-kun; Song, Zhiquan; Guan, Hua; Ma, Teng; Guo, Zongpei; Xie, Ying; Liu, Xiaodan; Han, Yang; Ma, T; Zhou, PK] Beijing Inst Radiat Med, Beijing Key Lab Radiobiol, Dept Radiat Toxicol & Oncol, Beijing 100850, Peoples R China.

[Xie, Ying] Hunan Normal Univ, Med Sch, Dept Prevent Med, Changsha 410078, Hunan, Peoples R China.

[Zhou, Ping-kun; Han, Yang] Univ South China, Sch Publ Hlth, Inst Environm Med & Radiat Hyg, Hengyang 421001, Hunan, Peoples R China.

[Ma, Teng] Capital Med Univ, Beijing TB & Thorac Tumor Res Inst, Beijing Chest Hosp, Dept Cellular & Mol Biol, Beijing 101149, Peoples R China.

通讯机构：

[Ma, T; Zhou, PK] B

[Zhou, Ping-kun] U

[Ma, Teng] C

Beijing Inst Radiat Med, Beijing Key Lab Radiobiol, Dept Radiat Toxicol & Oncol, Beijing 100850, Peoples R China.

Univ South China, Sch Publ Hlth, Inst Environm Med & Radiat Hyg, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

期刊：

信号转导与靶向治疗

ISSN：

2095-9907

年：

2019

卷：

期：

页码：

139-141

DOI：

10.1038/s41392-019-0057-6

基金类别：

This work was supported by grants from the National Key Basic Research Program (973 Program) of MOST, China (Grant No. 2015CB910601), the National Natural Science Foundation of China (Grant Nos. 31370843 and 31500681) to P. K. Zhou and the National Natural Science Foundation, China (Grant Nos. 31570853 and 81602799) to T. Ma.

机构署名：

本校为通讯机构

院系归属：

公共卫生学院

摘要：

Dear Editor, The DNA-dependent protein kinase catalytic subunit(DNA-PKcs)forms a serine/threonine protein kinase complex with the Ku heterodimer(Ku70/Ku80)and plays an important role in the DNA damage response(DDR)and maintenance of genomic stability through nonhomologous end joining(NHEJ), wherein the Ku heterodimer recognizes and binds broken DNA ends, facilitating the recruitment and activation of DNA-PKcs. Activated DNA-PKcs phosphorylates and alters the function of factors that mediate NHEJ, including DNA-PKcs itself. In addition, DDR-independent roles of DNA-PKcs have been demonstrated. ...

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Genome-wide identification of DNA-PKcs-associated RNAs by RIP-Seq

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