A recombinant multi-epitope peptide vaccine based on MOMP and CPSIT_p6 protein protects against Chlamydia psittaci lung infection

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Li, Yumeng;Zheng, Kang;Tan, Yuan;Wen, Yating;Wang, Chuan;...

通讯作者：

Wu, Yimou

作者机构：

[Wu, Yimou; Li, Yumeng; Tan, Manyi; Zheng, Kang; Wen, Yating; Wang, Chuan; Xu, Man; Chen, Qian] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hunan Prov Key Lab Special Pathogens Prevent & Co, Inst Pathogen Biol,Med Coll, Hengyang 421001, Peoples R China.

[Tan, Yuan] First Hosp Changsha, Dept Dermatol, Changsha 410000, Hunan, Peoples R China.

[Yu, Jian] Univ South China, Med Coll, Dept Expt Zool, Hengyang 421001, Peoples R China.

通讯机构：

[Wu, Yimou] U

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hunan Prov Key Lab Special Pathogens Prevent & Co, Inst Pathogen Biol,Med Coll, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

Chlamydia psittaci;Epitope;Vaccine;Major outer membrane protein;Chlamydial infection

期刊：

Applied Microbiology and Biotechnology

ISSN：

0175-7598

年：

2019

卷：

103

期：

页码：

941-952

DOI：

10.1007/s00253-018-9513-4

基金类别：

Acknowledgments This work was supported by the National Natural Science Foundation of China (Grant No. 81671986, Grant No. 31600150), the Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control Foundation (Grant No. 2014-5), the Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (Grant No. 2015-351), and the Foundation of the First Hospital of Changsha City (Grant No. Y2018-18).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Chlamydia psittaci is an obligate intracellular pathogen with a broad host range that can lead to severe infectious disease by transferring from birds to humans. Vaccination has been considered the best way to prevent chlamydial infection; nevertheless, there is currently still no commercially available vaccine that can inhibit the spread of C. psittaci. In previous study, major outer membrane protein (MOMP) of C. psittaci was confirmed to be an appropriate candidate antigen for limiting C. psittaci respiratory infections in a murine model, and...

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A recombinant multi-epitope peptide vaccine based on MOMP and CPSIT_p6 protein protects against Chlamydia psittaci lung infection

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