TRIM65 E3 ligase targets VCAM-1 degradation to limit LPS-induced lung inflammation

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成果类型：

期刊论文

作者：

Li, Yong;Huang, Xuan;Guo, Fang;Lei, Tianhua;Li, Shitao;...

通讯作者：

Fu, Mingui;Xin, Hong-Bo

作者机构：

[Monaghan-Nichols, Paula; Guo, Fang; Li, Yong; Fu, Mingui; Lei, Tianhua; Huang, Xuan] Univ Missouri, Sch Med, Dept Biomed Sci, Kansas City, MO 64108 USA.

[Xin, Hong-Bo; Huang, Xuan] Nanchang Univ, Inst Translat Med, Nanchang 330031, Jiangxi, Peoples R China.

[Guo, Fang; Jiang, Zhisheng] Univ South China, Inst Cardiovasc Dis, Dept Pathophysiol, Hengyang Med Coll, Hengyang 421001, Peoples R China.

[Li, Shitao] Oklahoma State Univ, Dept Physiol Sci, Ctr Vet & Hlth Sci, Stillwater, OK 74078 USA.

通讯机构：

[Fu, Mingui] U

[Xin, Hong-Bo] N

Univ Missouri, Sch Med, Dept Biomed Sci, Kansas City, MO 64108 USA.

Nanchang Univ, Inst Translat Med, Nanchang 330031, Jiangxi, Peoples R China.

语种：

英文

关键词：

TRIM65;VCAM-1;endothelial activation;lung inflammation;ubiquitination

期刊：

分子细胞生物学报：英文版

ISSN：

1674-2788

年：

2020

卷：

期：

页码：

190-201

DOI：

10.1093/jmcb/mjz077

基金类别：

American Heart AssociationAmerican Heart Association [17AIREA33660073]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [91639106]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Although the adhesion molecules-mediated leukocyte adherence and infiltration into tissues is an important step of inflammation, the post-translational regulation of these proteins on the endothelial cells is poorly understood. Here, we report that TRIM65, an ubiquitin E3 ligase of tripartite protein family, selectively targets vascular cell adhesion molecule 1 (VCAM-1) and promotes its ubiquitination and degradation, by which it critically controls the duration and magnitude of sepsis-induced pulmonary inflammation. TRIM65 is constitutively ex...

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