PI3K/Akt/mTOR signaling orchestrates the phenotypic transition and chemo-resistance of small cell lung cancer

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成果类型：

期刊论文

作者：

Li, Xuefeng;Li, Cheng;Guo, Chenchen;Zhao, Qiqi;Cao, Jiayu;...

通讯作者：

Yujuan Jin<&wdkj&>Liang Hu<&wdkj&>Hongbin Ji

作者机构：

[Zhao, Qiqi; Yue, Meiting; Xue, Yun; Li, Xuefeng; Huang, Hsin-Yi; Jin, Yujuan; Ji, Hongbin; Guo, Chenchen; Hu, Liang] Chinese Acad Sci, Ctr Excellence Mol Cell Sci, Shanghai Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China.

[Zhao, Qiqi; Yue, Meiting; Xue, Yun; Cao, Jiayu; Li, Xuefeng; Ji, Hongbin; Guo, Chenchen] Univ Chinese Acad Sci, Beijing 100049, Peoples R China.

[Li, Cheng; Li, Xuefeng] Univ South China, Hengyang Med Sch, Affiliated Hosp 1, Dept Med Oncol, Hengyang 421001, Hunan, Peoples R China.

[Zhao, Qiqi; Ji, Hongbin] Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 200120, Peoples R China.

[Cao, Jiayu] Chinese Acad Sci, CAS MPG Partner Inst Computat Biol, Shanghai Inst Nutr & Hlth, Shanghai Inst Biol Sci,CAS Key Lab Computat Biol, Shanghai 200031, Peoples R China.

通讯机构：

[Yujuan Jin; Liang Hu; Hongbin Ji] S

State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China<&wdkj&>University of Chinese Academy of Sciences, Beijing 100049, China<&wdkj&>School of Life Science and Technology, Shanghai Tech University, Shanghai 200120, China<&wdkj&>School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China<&wdkj&>State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China

语种：

英文

关键词：

SCLC;Heterogeneity;Growth pattern;Phenotype transition;Drug resistance;PI3K/Akt/mTOR pathway

期刊：

遗传学报

ISSN：

1673-8527

年：

2021

卷：

期：

页码：

640-651

DOI：

10.1016/j.jgg.2021.04.001

基金类别：

supported by the National Natural Science Foundation of China （82030083 to H.J., 81871875 to L.H.）； the National Basic Research Program of China （2017YFA0505501 to H.J.; 2020YFA0803300 to H.J.）； the Strategic Priority Research Program of the Chinese Academy of Sciences （XDB19020201 to H.J.）； the National Natural Science Foundation of China （81872312 to H.J., 82011540007 to H.J., 31621003 to H.J., 81402371 to Y.J., 81802279 to H.H., 81902326 to X.W., 81602443 to X.L.）； the Basic Frontier Scientific Research Program of Chinese Academy of Science （ZDBSLY-SM006 to H.J.）； the International Cooperation Project of Chinese Academy of Sciences （153D31KYSB20190035 to H.J.）； the Youth Innovation Promotion Association CAS （Y919S31371 to X.W.）； the Natural Science Foundation of Hunan Province, China （2019JJ50550 to X.L.）； Clinical Medical Technology Innovation Guide Project of Hunan （2020SK51827 to X.L.）； Project of Scientific Research Plan of Hunan Provincial Health Commission （202103100127 to X.L.）；

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Small cell lung cancer (SCLC) is a phenotypically heterogeneous disease with an extremely poor prognosis, which is mainly attributed to the rapid development of resistance to chemotherapy. However, the relation between the growth phenotypes and chemo-resistance of SCLC remains largely unclear. Through comprehensive bioinformatic analyses, we found that the heterogeneity of SCLC phenotype was significantly associated with different sensitivity to chemotherapy. Adherent or semiadherent SCLC cells were enriched with activation of the PI3K/Akt/mTOR pathway and were highly chemoresistant. Mechanist...

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PI3K/Akt/mTOR signaling orchestrates the phenotypic transition and chemo-resistance of small cell lung cancer

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