National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30801335, 81071620, 81072198]; Hunan Provincial Foundation of China [09C833]; Foundation of the Construct Program of the Key Discipline in Hunan Province [2006-180]; Scientific Research Initial Foundation of University of South China for Post-doctor [2007XQD25]
机构署名：
本校为第一且通讯机构
院系归属：
医学院
摘要：
Epstein-Barr virus (EBV) has a close association with various types of human lymphomas. Animal models are essential to elucidate the pathogenesis of human EBV-associated lymphomas. The aim of the present study is to evaluate the association between human IgG concentration and EBV-associated lymphoma development in huPBL/SCID mice. Human peripheral blood lymphocytes (hu-PBL) from EBV-seropositive donors were inoculated intraperitoneally into SCID mouse. Immunohistochemical staining was used to examine differentiated antigens of tumor cells. EBV infection of the induced tumors was detected by in...
