This work was supported by the grants from the National Natural Science Foundation of China (82073488, 81773359 and 31470827) to Yongqing Gu, the National Natural Science Foundation of China (81530085) to Ping-Kun Zhou.
机构署名：
本校为其他机构
院系归属：
公共卫生学院
摘要：
Radiation-induced pulmonary fibrosis (RIPF) is a major lung complication in using radiotherapy to treat thoracic diseases. MicroRNAs (miRNAs) are reported to be the therapeutic targets for many diseases. However, the miRNAs involved in the pathogenesis of RIPF are rarely studied as potential therapeutic targets. Alveolar epithelial cells participate in RIPF formation by undergoing epithelial-mesenchymal transition (EMT). Here we demonstrated the critical role of miR-155-5p in radiation-induced EMT and RIPF. Using the previously established EMT cell model, we found that miR-155-5p was significa...
