期刊论文

Zeng, Ying;Zeng, Xi

英文

Clinica Chimica Acta

0009-8981

2020

500

220-225

10.1016/j.cca.2019.10.021

This work was funded by the National Natural Science Foundation of China (No. 81641112 ), Natural Science Foundation of Hunan Province of China (No. 2019JJ40254 ), Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study ( 2014-405 ), and Foundation of the Construct Program of the Key Discipline in Hunan Province of China (2011-76), We thank Prof. Qian Tao, State Key Laboratory of Translational Oncology in South China, Department of Clinical Oncology, the Chinese University of Hong Kong, for their comments on the manuscript.

本校为第一且通讯机构

Zinc finger protein 382 (ZNF382), a member of the Kruppel-associated box zinc finger proteins (KRAB-ZFPs) family, plays critical roles in regulating certain downstream genes expression as a transcription inhibitor. ZNF382 is downregulated in multiple tumors due to hypermethylation of its promoter, to be more specific, methylation of promoter CpG island may contributes to inhibition of gene expression as found in many studies. With application of DNA methyltransferase inhibitors (DNMTi) 5-azacytidine and 5-aza-2'-deoxycytidine, hypomethylation of ZNF382 gene may contribute to anti-tumor effects...