期刊论文

Li, Jun

英文

Parasites & Vectors

1756-3305

2021

14

1

1-11

10.1186/s13071-021-04677-7

We are grateful to Dr. Yuan Liu at the Department of Chemistry and Biochemistry, Florida International University, for providing the human kidney cells used in this study. This work was supported by NIH R01AI125657 and NSF Career Awards 1453287 and 1742644 to Jun Li. Dr. Yue Hao is a visiting scholar at the Florida International University, supported by a China Scholarship Council Grant #201808430054.

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Abstract Background Malaria transmission depends on infected mosquitoes and can be controlled by transmission-blocking drugs. The recently discovered FREP1-mediated malaria transmission pathway is an excellent target to screen drugs for limiting transmission. Methods To identify candidate small molecules, we used an ELISA-based approach to analyze extracts from a fungal library for inhibition of the FREP1–parasite interaction. We isolated and determined one active compound by chromatography and crystallography, respectively. We measured ...