A novel fungal metabolite inhibits Plasmodium falciparum transmission and infection

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Niu, Guodong;Wang, Xiaohong;Hao, Yue;Kandel, Shambhu;Niu, Guomin;...

通讯作者：

Li, Jun

作者机构：

[Li, Jun; Wang, Xiaohong; Niu, Guodong; Hao, Yue] Florida Int Univ, Dept Biol Sci, 11200 SW 8th St, Miami, FL 33199 USA.

[Raptis, Raphael G.; Kandel, Shambhu] Florida Int Univ, Dept Chem & Biochem, 11200 SW 8th St, Miami, FL 33199 USA.

[Li, Jun; Raptis, Raphael G.] Florida Int Univ, Biomol Sci Inst, 11200 SW 8th St, Miami, FL 33199 USA.

[Niu, Guomin] Southern Med Univ, Affiliated Nanhai Hosp, Dept Hematol, Guangzhou, Guangdong, Peoples R China.

[Hao, Yue] Univ South China, Coll Publ Hlth, Hengyang, Hunan, Peoples R China.

通讯机构：

[Li, Jun] F

Florida Int Univ, Dept Biol Sci, 11200 SW 8th St, Miami, FL 33199 USA.

语种：

英文

关键词：

Fungal metabolites;Antimalarial agent;Malaria;Mosquito;FREP1-mediated Plasmodium transmission;Purpureocillium lilacinum

期刊：

Parasites & Vectors

ISSN：

1756-3305

年：

2021

卷：

期：

页码：

1-11

DOI：

10.1186/s13071-021-04677-7

基金类别：

NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01AI125657]; NSFNational Science Foundation (NSF) [1453287, 1742644]; China Scholarship CouncilChina Scholarship Council [201808430054]

机构署名：

本校为其他机构

院系归属：

公共卫生学院

摘要：

BACKGROUND: Malaria transmission depends on infected mosquitoes and can be controlled by transmission-blocking drugs. The recently discovered FREP1-mediated malaria transmission pathway is an excellent target to screen drugs for limiting transmission. METHODS: To identify candidate small molecules, we used an ELISA-based approach to analyze extracts from a fungal library for inhibition of the FREP1-parasite interaction. We isolated and determined one active compound by chromatography and crystallography, respectively. We measured the effects of...

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A novel fungal metabolite inhibits Plasmodium falciparum transmission and infection

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