Anticancer effects of Mahanimbine alkaloid on the human bladder cancer cells are due to the induction of G0/G1 cell cycle arrest, apoptosis and autophagy

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成果类型：

期刊论文

作者：

Xie, Huang;Zhang, Tao;Yang, Ning;Li, Zhijun;Liu, Yimin*

通讯作者：

Liu, Yimin

作者机构：

[Li, Zhijun; Xie, Huang; Zhang, Tao; Yang, Ning] Univ South China, Affiliated Hosp 2, Dept Urinary Surg, Hengyang, Hunan, Peoples R China.

[Liu, Yimin] Univ South China Hengyang, Dept Anesthesiol, Affiliated Nanhua Hosp, 336 Dongfeng South Rd, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Liu, Yimin] U

Univ South China Hengyang, Dept Anesthesiol, Affiliated Nanhua Hosp, 336 Dongfeng South Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

acridine orange;alkaloid;ethidium bromide;lipocortin 5;mahanimbine;propidium iodide;protein Bax;protein bcl 2;sequestosome 1;unclassified drug;alkaloid;carbazole derivative;fused heterocyclic rings;mahanimbine;apoptosis;Article;autophagy (cellular);bladder cancer cell line;cell cycle;cell cycle arrest;cell cycle phase;cell structure;cell viability;cell viability assay;chemical structure;concentration response;controlled study;cytotoxicity;flow cytometry;fluorescence microscopy;G1 phase cell cycle checkpoint;human;human cell;IC50;protein expression;transmission electron microscopy;Western blotting;apoptosis;autophagy;bladder tumor;cell cycle checkpoint;drug effect;genetics;Alkaloids;Apoptosis;Autophagy;Carbazoles;Cell Cycle Checkpoints;Heterocyclic Compounds, 4 or More Rings;Humans;Urinary Bladder Neoplasms

期刊：

Journal of BUON

ISSN：

1107-0625

年：

2020

卷：

期：

页码：

1166-1171

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Purpose: The main purpose of the current research work was to investigate the anticancer effects of Mahanimbine alkaloid in human bladder cancer cells along with examining its effects on cellular apoptosis, cell cycle phase distribution, and cell autophagy. Methods: Cell viability was examined by WST-1 cell viability assay. Mahanimbine-induced apoptosis was examined by fluorescent microscopy using acridine orange (AO)/ethidium bromide (EB) staining as well as using flow cytometry in combination with annexin-v/propidium iodide (PI) staining. Fur...

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Anticancer effects of Mahanimbine alkaloid on the human bladder cancer cells are due to the induction of G0/G1 cell cycle arrest, apoptosis and autophagy

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