Triple Functional AB(2) Unit-Modulated Facile Preparation of Bioreducible Hyperbranched Copolymers

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成果类型：

期刊论文

作者：

Liu, Yuping;Cong, Yong;Ma, Wei;Kang, Guiying;Meng, Chao;...

通讯作者：

Yu, Cuiyun;Wei, Hua

作者机构：

[Liu, Yuping; Wei, Hua; Cong, Yong; Ma, Wei; Meng, Chao; Kang, Guiying; Liu, Fangjun] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Gansu, Peoples R China.

[Wei, Hua; Yu, Cuiyun; Wei, H] Univ South China, Dept Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

通讯机构：

[Yu, CY; Wei, H] U

[Wei, Hua] L

Univ South China, Dept Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Gansu, Peoples R China.

语种：

英文

关键词：

AB(2) unit;click coupling;RAFT polymerization;hyperbranched polymer template;controlled drug release

期刊：

ACS BIOMATERIALS SCIENCE & ENGINEERING

ISSN：

2373-9878

年：

2020

卷：

期：

页码：

2812-2821

DOI：

10.1021/acsbiomaterials.0c00261

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China [51473072, 21504035]; Thousand Young Talent Program; Outstanding Youth Fund of Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2017JJ1024]; National Key R&D Program of China [2018YFB1900201]; Open Research Fund of State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences

机构署名：

本校为通讯机构

院系归属：

药学与生物科学学院

摘要：

Facile preparation of hyperbranched polymers (HPs) has been advanced tremendously by the use of either various multifunctional agent-mediated controlled living radical polymerizations or a highly reactive ABx unit-modulated self-stepwise polymerizations. However, it remains, to our knowledge, a significant challenge to prepare HPs with simultaneously precisely controlled degree of branching (DB) and biorelevant signal-triggered degradation property for controlled release applications due to the respective limitations of the aforementioned two s...

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Triple Functional AB(2) Unit-Modulated Facile Preparation of Bioreducible Hyperbranched Copolymers

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