The D Domain of LRRC4 anchors ERK1/2 in the cytoplasm and competitively inhibits MEK/ERK activation in glioma cells

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成果类型：

期刊论文

作者：

Wang, Zeyou;Guo, Qin;Wang, Rong;Xu, Gang;Li, Peiyao;...

通讯作者：

Li, Guiyuan;Wu, Minghua

作者机构：

[She, Xiaoling; Wang, Zeyou; Xiong, Jing; Wang, Rong; Li, Guiyuan; Wu, MH; Wu, Minghua; Yu, Zhibin; Li, Peiyao; Liu, Changhong; Xu, Gang] Cent S Univ, Xiangya Hosp, Chinese Minist Hlth, Key Lab Carcinogenesis, Changsha 410008, Hunan, Peoples R China.

[She, Xiaoling; Wang, Zeyou; Xiong, Jing; Wang, Rong; Li, Guiyuan; Wu, MH; Wu, Minghua; Yu, Zhibin; Li, Peiyao; Liu, Changhong; Xu, Gang] Cent S Univ, Canc Res Inst, Key Lab Carcinogenesis & Canc Invas, Chinese Minist Educ, Changsha 410008, Hunan, Peoples R China.

[She, Xiaoling; Wang, Zeyou; Wang, Rong; Li, Guiyuan; Wu, MH; Liu, Qiang; Wu, Minghua; Guo, Qin; Yu, Zhibin; Li, Peiyao; Liu, Changhong] Cent S Univ, Hunan Key Lab Nonresolving Inflammat & Canc, Dis Genome Res Ctr, Xiangya Hosp 3, Changsha 410013, Hunan, Peoples R China.

[Wang, Zeyou] Cent S Univ, Xiangya Hosp 2, Dept Lab Med, Changsha 410011, Hunan, Peoples R China.

[Xu, Gang] Univ South China, Coll Med, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Li, GY; Wu, MH] C

Cent S Univ, Xiangya Hosp, Chinese Minist Hlth, Key Lab Carcinogenesis, Changsha 410008, Hunan, Peoples R China.

Cent S Univ, Canc Res Inst, Key Lab Carcinogenesis & Canc Invas, Chinese Minist Educ, Changsha 410008, Hunan, Peoples R China.

Cent S Univ, Hunan Key Lab Nonresolving Inflammat & Canc, Dis Genome Res Ctr, Xiangya Hosp 3, Changsha 410013, Hunan, Peoples R China.

语种：

英文

关键词：

Leucine-rich repeat;D domain;CD domain;ERK1/2;MAPK

期刊：

Journal of Hematology & Oncology

ISSN：

1756-8722

年：

2016

卷：

期：

页码：

1-13

DOI：

10.1186/s13045-016-0355-1

基金类别：

National Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81301708]; National Key Technology Research, and Development Program of the Ministry of Science and Technology of ChinaNational Key Technology R&D Program [2014BAI04B02]; 111 projectMinistry of Education, China - 111 Project [111-2-12]; Open-End Fund for the Valuable and Precison Instruments of Central South University [CSUZC2014050]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Background: As a well-characterized key player in various signal transduction networks, extracellular-signal-regulated kinase (ERK1/2) has been widely implicated in the development of many malignancies. We previously found that Leucine-rich repeat containing 4 (LRRC4) was a tumor suppressor and a negative regulator of the ERK/MAPK pathway in glioma tumorigenesis. However, the precise molecular role of LRRC4 in ERK signal transmission is unclear. Methods: The interaction between LRRC4 and ERK1/2 was assessed by co-immunoprecipitation and GST pul...

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The D Domain of LRRC4 anchors ERK1/2 in the cytoplasm and competitively inhibits MEK/ERK activation in glioma cells

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