Urotensin II increases foam cell formation by repressing ABCA1 expression through the ERK/NF-κB pathway in THP-1 macrophages

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成果类型：

期刊论文

作者：

Wang, Yan;Wu, Jian-Feng;Tang, Yan-Yan;Zhang, Min;Li, Yuan;...

通讯作者：

Zeng, Gao-Feng

作者机构：

[Wang, Yan] Univ South China, Affiliated Hosp 2, Dept Anesthesiol, Hengyang 421001, Hunan, Peoples R China.

[Li, Yuan; Tang, Chao-Ke; Xie, Wei; Tang, Yan-Yan; Yao, Feng; Zhang, Min] Univ South China, Key Lab Atherosclerol Hunan Prov, Inst Cardiovasc Res, Hengyang 421001, Hunan, Peoples R China.

[Wu, Jian-Feng; Chen, Kong; Zeng, Meng-Ya; Zeng, Gao-Feng] Univ South China, Affiliated Hosp 2, Dept Cardiovasc Med, Hengyang 421001, Hunan, Peoples R China.

[Zheng, Xi-Long] Univ Calgary, Dept Biochem & Mol Biol, Libin Cardiovasc Inst Alberta, Hlth Sci Ctr, Calgary, AB T2N 4N1, Canada.

通讯机构：

[Zeng, Gao-Feng] U

Univ South China, Affiliated Hosp 2, Dept Cardiovasc Med, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

ABCA1;Cholesterol efflux;ERK;NF-kappaB;Urotensin II

期刊：

Biochemical and Biophysical Research Communications

ISSN：

0006-291X

年：

2014

卷：

452

期：

页码：

998-1003

DOI：

10.1016/j.bbrc.2014.09.030

基金类别：

The authors gratefully acknowledge the financial support from the National Natural Sciences Foundation of China ( 81170278 and 81370377 ). Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province ( 2008-244 ) and the construct program of the key discipline in Hunan Province, China.

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Objective Foam cell formation in the arterial wall plays a key role in the development of atherosclerosis. Recent studies showed that Urotensin II (U II) is involved in the pathogenesis of atherosclerosis. Here we examined the effects of human U II on ATP-binding cassette transporter A1 (ABCA1) expression and the underlying mechanism in THP-1 macrophages. Methods and results Cultured THP-1 macrophages were treated with U II, followed by measuring the intracellular lipid contents, cholesterol efflux and ABCA1 levels. The results showed that U II...

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Urotensin II increases foam cell formation by repressing ABCA1 expression through the ERK/NF-κB pathway in THP-1 macrophages

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