Diallyl disulfide induces DNA damage and growth inhibition in colorectal cancer cells by promoting POU2F1 ubiquitination

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成果类型：

期刊论文

作者：

Xia, Longzheng;Lin, Jinguan;Peng, Mingjing;Jiang, Xianjie;Peng, Qiu;...

通讯作者：

Shi, Yingrui;Liao, Qianjin;Zhou, YJ

作者机构：

[Xia, Longzheng; Jiang, Xianjie; Wang, Jiewen; Oyang, Linda; Zhang, Wenlong; Shi, Yingrui; Peng, Mingjing; Luo, Xia; Zhou, Yujua; Liao, Qianjin; Li, Shizhen; Cui, Shiwen; Tang, Yanyan; Tan, Shiming; Hu, Zifan; Ren, Zongyao; Wu, Nayiyuan; Peng, Qiu; Lin, Jinguan] Cent South Univ, Hunan Canc Hosp, Hunan Key Lab Canc Metab, Changsha 410013, Hunan, Peoples R China.

[Xia, Longzheng; Jiang, Xianjie; Wang, Jiewen; Oyang, Linda; Zhang, Wenlong; Shi, Yingrui; Peng, Mingjing; Luo, Xia; Zhou, Yujua; Liao, Qianjin; Li, Shizhen; Cui, Shiwen; Tang, Yanyan; Tan, Shiming; Hu, Zifan; Ren, Zongyao; Wu, Nayiyuan; Peng, Qiu; Lin, Jinguan] Cent South Univ, Xiangya Sch Med, Affiliated Canc Hosp, Changsha 410013, Hunan, Peoples R China.

[Zhou, Yujua; Liao, Qianjin; Cui, Shiwen] Univ South China, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Zhou, Yujua; Liao, Qianjin] Publ Serv Platform Tumor Organoids Technol, 283 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China.

[Liao, Qianjin; Shi, Yingrui; Zhou, Yujua; Shi, YR; Zhou, YJ] Cent South Univ, Hunan Canc Hosp, 283 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China.

通讯机构：

[Liao, QJ; Shi, YR; Zhou, YJ ] C

Cent South Univ, Hunan Canc Hosp, 283 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China.

Cent South Univ, Affiliated Canc Hosp, Xiangya Sch Med, 283 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China.

语种：

英文

关键词：

DNA damage;POU2F1 ubiquitination;apoptosis;diallyl disulfide;the pentose phosphate pathway

期刊：

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES

ISSN：

1449-2288

年：

2024

卷：

期：

页码：

1125-1141

DOI：

10.7150/ijbs.91206

基金类别：

National Natural Science Foundation of China [82173142, 81872281]; Natural Science Foundation of Hunan Province [2023JJ60469, 2023JJ30372, 2022JJ80078]; Science and technology innovation Program of Hunan Province [2023RC1073, 2023RC3199]; Research Project of Health Commission of Hunan Province [202203034978, 202109031837, 20201020]; Hunan Provincial Science and Technology Department [2020TP1018]; Changsha Science and Technology Board [kh2201054]; Ascend Foundation of National cancer center [NCC201909B06]; Hunan Cancer Hospital Climb Plan [ZX2020001-3, YF2020002]

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本校为其他机构

摘要：

Previous studies have demonstrated that diallyl disulfide (DADS) exhibits potent anti-tumor activity. However, the pharmacological actions of DADS in inhibiting the growth of colorectal cancer (CRC) cells have not been clarified. Herein, we show that DADS treatment impairs the activation of the pentose phosphate pathway (PPP) to decrease PRPP (5-phosphate ribose-1-pyrophosphate) production, enhancing DNA damage and cell apoptosis, and inhibiting the growth of CRC cells. Mechanistically, DADS treatment promoted POU2F1 K48-linked ubiquitination and degradation by attenuating the PI3K/AKT signali...

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Diallyl disulfide induces DNA damage and growth inhibition in colorectal cancer cells by promoting POU2F1 ubiquitination

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