LncRNA SNHG12 inhibits miR-199a to upregulate SIRT1 to attenuate cerebral ischemia/reperfusion injury through activating AMPK signaling pathway

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成果类型：

期刊论文

作者：

Yin, Wei-Lan;Yin, Wei-Guo;Huang, Bai-Sheng;Wu, Li-Xiang*

通讯作者：

Wu, Li-Xiang

作者机构：

[Wu, Li-Xiang; Yin, Wei-Lan; Huang, Bai-Sheng] Cent S Univ, Dept Physiol, Sch Basic Med Sci, 110 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.

[Yin, Wei-Lan] Univ South China, Coll Med, Inst Neurosci, Hengyang 421001, Peoples R China.

[Yin, Wei-Guo] Guangzhou Med Univ, Qingyuan City Peoples Hosp, Affiliated Hosp 6, Mol Diagnost Ctr, Qingyuan 511518, Peoples R China.

[Yin, Wei-Guo] Shantou Univ, Coll Med, Yuebei Peoples Hosp, Dept Clin Lab, Shaoguan 512026, Peoples R China.

通讯机构：

[Wu, Li-Xiang] C

Cent S Univ, Dept Physiol, Sch Basic Med Sci, 110 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.

语种：

英文

关键词：

*AMPK pathway;*Cerebral I/R injury;*SIRT1;*SNHG12;*miR-199a

期刊：

Neuroscience Letters

ISSN：

0304-3940

年：

2019

卷：

690

页码：

188-195

DOI：

10.1016/j.neulet.2018.08.026

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81472160, 81200986]; Natural Science Foundation of Guangdong Province, ChinaNational Natural Science Foundation of Guangdong Province [2015A030313691]; Public Research and Capacity Building Project of Guangdong Province, China [2014A020212036]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Cerebral ischemia caused severe disability, and associated with a series of neurological events. Long non-coding RNA SNHG12 was found to be upregulated in mouse brain microvascular endothelial cells by cerebral ischemia. Moreover, it was reported that SNHG12 could directly interact with miR-199a and sirtuin 1 (SIRT1) as a direct target of miR-199a in other diseases. However, the function and mechanism of SNHG12 in cerebral ischemia and reperfusion (I/R) injury of neuronal cells remains unclear. The present study was thus designed to explore the potential effect of SNHG12 and to investigate the...

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LncRNA SNHG12 inhibits miR-199a to upregulate SIRT1 to attenuate cerebral ischemia/reperfusion injury through activating AMPK signaling pathway

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