Evaluation of the safety, biodistribution, dosimetry of [18F]AlF-NYM005 and initial experience in clear cell renal cell carcinoma: an interim analysis of a prospective trial - 成果

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Evaluation of the safety, biodistribution, dosimetry of [¹⁸F]AlF-NYM005 and initial experience in clear cell renal cell carcinoma: an interim analysis of a prospective trial

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Yang, Liping;Guo, Wei;Ding, Hongchao;Gao, Xing;Xu, Yuchao;...

通讯作者：

Cheng, Liang;Wang, KZ;Meng, HX

作者机构：

[Wang, Wenzhi; Yang, Xinyue; Liu, Wei; Hou, Dayong; Yang, Liping; Wang, Menglu; Zhao, Yue; Cheng, Liang; Guo, Wei; Jia, Fan; Wang, Kezheng] Harbin Med Univ, Dept PET CT, Canc Hosp, Harbin 150001, Peoples R China.

[Ding, Hongchao] Harbin Med Univ, Affiliated Hosp 1, Dept Magnet Resonance Imaging, Harbin, Peoples R China.

[Gao, Xing] Harbin Med Univ, Affiliated Hosp 2, Dept Ultrasound, Harbin, Peoples R China.

[Xu, Yuchao] Univ South China, Sch Nucl Sci & Technol, Hengyang, Hunan, Peoples R China.

[Meng, Hongxue; Nanding, Abiyasi; Meng, HX] Harbin Med Univ, Dept Pathol, Canc Hosp, Harbin 150001, Peoples R China.

通讯机构：

[Cheng, L; Meng, HX ; Wang, KZ ] H

Harbin Med Univ, Dept PET CT, Canc Hosp, Harbin 150001, Peoples R China.

Harbin Med Univ, Dept Pathol, Canc Hosp, Harbin 150001, Peoples R China.

语种：

英文

关键词：

Biodistribution;Carbonic anhydrase IX;Clear cell renal cell carcinoma;PET/CT imaging;Radiation dosimetry;[18F]AlF-NYM005

期刊：

European Journal of Nuclear Medicine and Molecular Imaging

ISSN：

1619-7070

年：

2025

卷：

期：

页码：

1354-1369

DOI：

10.1007/s00259-024-07007-y

基金类别：

This study was sponsored in part by the Provincial Key Research and Development Program of Heilongjiang Province (GA21C001), Distinguished Young Scientist Funding of Harbin Medical University Affiliated Tumor Hospital (JCQN2019-02), Key Project of Harbin Medical University Cancer Hospital Climbing Funding (PDYS2024-03), Key Innovation Technology Project Harbin Medical University Cancer (Hospital Innovation Technology Funding (CXJSZD-2023-04), Heilongjiang Province’s “unveiling and leading” technology research and development project (2022ZXJ03C01).The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

机构署名：

本校为其他机构

院系归属：

核科学技术学院

摘要：

PURPOSE: This first-in-human study aimed to evaluate the radiation dosimetry and whole-body biodistribution of [(18)F]AlF-NYM005, a novel small-molecule carbonic anhydrase IX (CAIX) targeting agent, and to investigate its ability to detect CAIX-positive tumors using PET scans in a cohort of clear cell renal cell carcinoma (ccRCC) patients. METHODS: [(18)F]AlF-NYM005 was synthesized using a fully automatic cassette module Mortenon M1 (Nuoyu, China). Thirty-five patients with a suspicious lesion considered primary renal malignancy or a history of...

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Evaluation of the safety, biodistribution, dosimetry of [¹⁸F]AlF-NYM005 and initial experience in clear cell renal cell carcinoma: an interim analysis of a prospective trial

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