Increased level of lipoprotein(a)[Lp(a)] had been identified as an independent risk factor for coronary and peripheral blood disease. Here, we studied the impact of Lp(a) (20μg/ml) on endothelial progenitor cells (EPCs) and determined whether Lp(a) affected EPCs by an inhibitory effect on its neovascularization, as it had cleared that EPCs involved the incorporation of postnatal neovascularization. EPCs were isolated from mouse bone marrow and cultured by differential attachment method. In vivo, we demonstrated that Lp(a) inhibited EPCs migrat...
