Association of Reduced Brain Metabolism With Motor Function and Survival in Amyotrophic Lateral Sclerosis Patients With Neurofilament Heavy (NEFH) Gene Mutation

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成果类型：

期刊论文

作者：

Song, Xinyu;Wang, Xueying;Hu, Fan;Liu, Pan;Liu, Ziqin;...

通讯作者：

Wang, JL;Zhang, YC;Yi, XP

作者机构：

[Liu, Ziqin; Song, Xinyu; Wang, Junling; Cao, Wenfeng; Hu, Fan; Xu, Renxu; Liu, Pan] Cent South Univ, Xiangya Hosp, Jiangxi Natl Reg Ctr Neurol Dis, Nanchang, Jiangxi, Peoples R China.

[Wang, Xueying] Cent South Univ, Xiangya Hosp, Dept Radiol, Changsha, Hunan, Peoples R China.

[Cao, Wenfeng; Hu, Fan; Xu, Renxu] Nanchang Med Coll, Affiliated Hosp 1, Nanchang Med Coll, Dept Neurol,Jiangxi Prov Peoples Hosp,Clin Coll, Nanchang, Jiangxi, Peoples R China.

[Yi, Jiping] Univ South China, Xiangnan Univ 1, Dept Neurol, Peoples Hosp Chenzhou 1,Affiliated Hosp, R China, Chenzhou, Peoples R China.

[Zhang, Yuanchao] Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu, Sichuan, Peoples R China.

通讯机构：

[Wang, JL ; Yi, XP ] C

[Zhang, YC ] U

Cent South Univ, Xiangya Hosp, Jiangxi Natl Reg Ctr Neurol Dis, Nanchang, Jiangxi, Peoples R China.

Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu, Sichuan, Peoples R China.

Arizona State Univ, Coll Hlth Solut, Tempe, AZ USA.

语种：

英文

关键词：

18F‐FDG‐PET/CT 18F‐fluorodeoxyglucose positron emission tomography (PET)/computed tomography (CT);amyotrophic lateral sclerosis;brain glucose metabolism;mediation effect;neurofilament heavy (NEFH) gene

期刊：

European Journal of Neurology

ISSN：

1351-5101

年：

2025

卷：

期：

页码：

e70261

DOI：

10.1111/ene.70261

基金类别：

National Key Research and Development Program of China

机构署名：

本校为其他机构

摘要：

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that impairs both upper and lower motor neurons. Mutations in the neurofilament heavy (NEFH) gene are associated with a higher risk for ALS. This study aimed to evaluate the brain metabolism in patients with ALS and NEFH gene mutations (NEFH-ALS) and assess its correlation with emotional and cognitive changes. METHODS: This prospective study enrolled 119 patients with ALS and 128 age- and gender-matched health controls. Study assessments included demographic da...

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Association of Reduced Brain Metabolism With Motor Function and Survival in Amyotrophic Lateral Sclerosis Patients With Neurofilament Heavy (NEFH) Gene Mutation

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