Salinomycin exerts anticancer effects on PC-3 cells and PC-3-derived cancer stem cells in vitro and in vivo

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成果类型：

期刊论文

作者：

Zhang, Yunsheng;Liu, Luogen;Li, Fang;Wu, Tao;Jiang, Hongtao;...

通讯作者：

Wang, Yi

作者机构：

[Wang, Yi; Zhang, Yunsheng; Liu, Luogen] Univ South China, Affiliated Hosp 2, Clin Res Inst, Hengyang 421001, Peoples R China.

[Li, Fang] Hunan Polytech Environm & Biol, Coll Nursing, Hengyang 421005, Peoples R China.

[Wang, Yi; Wu, Tao; Jiang, Xianxun; Jiang, Hongtao] Univ South China, Affiliated Hosp 2, Dept Urol, Hengyang 421001, Peoples R China.

[Du, Xiaobo] First Peoples Hosp Yueyang, Dept Urol, Yueyang 414000, Peoples R China.

通讯机构：

[Wang, Yi] U

Univ South China, Affiliated Hosp 2, Clin Res Inst, Hengyang 421001, Peoples R China.

语种：

英文

期刊：

BioMed Research International

ISSN：

2314-6133

年：

2017

卷：

2017

页码：

4101653

DOI：

10.1155/2017/4101653

基金类别：

Zhengxiang Scholar Program of the University of South China; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81241090]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Salinomycin is an antibiotic isolated from Streptomyces albus that selectively kills cancer stem cells (CSCs). However, the antitumor mechanism of salinomycin is unclear. This study investigated the chemotherapeutic efficacy of salinomycin in human prostate cancer PC-3 cells. We found that cytotoxicity of salinomycin to PC-3 cells was stronger than to nonmalignant prostate cell RWPE-1, and exposure to salinomycin induced G2/M phage arrest and apoptosis of PC-3 cells. A mechanistic study found salinomycin suppressed Wnt/β-catenin pathway to ind...

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Salinomycin exerts anticancer effects on PC-3 cells and PC-3-derived cancer stem cells in vitro and in vivo

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