期刊论文

Zhou, Ping-Kun

英文

Cell Cycle

1538-4101

2012

11

18

3463-3471

10.4161/cc.21770

This work was supported by the National Key Basic Research Program (973 Program) of MOST (Grant 2007CB914603), the Chinese National Natural Science Foundation (Grant 81071678, 81272994 and 30970677) and the Distinguished Youth Scientist Foundation of NFSC (Grant 30825011).

本校为其他机构

The essential function of eIF4E-binding protein 1 (4E-BP1) in translation initiation has been well established; however, the role of 4E-BP1 in normal cell cycle progression is coming to attention. Here, we revealed the role of 4E-BP1 on mitotic regulation and chromosomal DNA dynamics during mitosis. First, we have observed the co-localization of the phosphorylated 4E-BP1 at T37/46 with Polo-like kinase 1 (PLK1) at the centrosomes during mitosis. Depression of 4E-BP1 by small interfering RNA in HepG2 or HeLa cells resulted in an increased outcom...