Synthesis of novel genistein amino acid derivatives and investigation on their interactions with bovine serum albumin by spectroscopy and molecular docking

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成果类型：

期刊论文

作者：

Long, Xiaokang;Zeng, Yao-Fu;Liu, Yunmei;Liu, Ying;Li, Tangluo;...

通讯作者：

Guo, Yu

作者机构：

[Liu, Yunmei; Liu, Ying; Li, Tangluo; Guo, Yu; Long, Xiaokang; Liao, Lanqing; Zeng, Yao-Fu] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.

通讯机构：

[Guo, Yu] U

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.

语种：

英文

期刊：

RSC Advances

ISSN：

2046-2069

年：

2018

卷：

期：

页码：

31201-31212

DOI：

10.1039/c8ra06691d

基金类别：

Construct Program of the Key Discipline in Hunan Province; Key and Youth Project of Hunan Provincial Education Department of China [17A190, 17B234]

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

Genistein amino acid derivatives 4a–4d were synthesized and evaluated for their cytotoxic activities against MCF-7, Hela, MGC-803 and HCT-116 cell lines by MTT assays in vitro. The results revealed that compounds 4a–4d showed better activity than the parent compound genistein. Particularly, compound 4b displayed the most significant anticancer activity against MGC-803 with an IC50 value of 12.08 μM. In addition, the mechanisms of interaction between genistein, compounds 4a–4d and BSA were investigated via multi-spectroscopic techniques such...

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Synthesis of novel genistein amino acid derivatives and investigation on their interactions with bovine serum albumin by spectroscopy and molecular docking

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