The association between S100A13 and HMGA1 in the modulation of thyroid cancer proliferation and invasion

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成果类型：

期刊论文

作者：

Zhong, Jing;Liu, Chang;Chen, Ya-jun;Zhang, Qing-hai;Yang, Jing;...

通讯作者：

Zu, Xu-yu;Cao, Ren-xian

作者机构：

[Zu, Xu-yu; Cao, Ren-xian; Zhong, Jing; Wen, Ge-bo; Chen, Si-Rui; Zhang, Qing-hai; Kang, Xuan; Liu, Chang; Chen, Ya-jun] Univ South China, Affiliated Hosp 1, Inst Clin Med, Hengyang 421001, Hunan, Peoples R China.

[Liu, Chang] First Peoples Hosp Chenzhou, Dept Endocrinol & Metab, Luojiajing Rd 102, Chenzhou 423000, Hunan, Peoples R China.

[Chen, Ya-jun] Univ South China, Affiliated Hosp 2, Dept Endocrinol & Metab, Hengyang 421001, Hunan, Peoples R China.

[Wen, Ge-bo; Yang, Jing; Cao, Ren-xian] Univ South China, Affiliated Hosp 1, Dept Endocrinol & Metab, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Zu, XY; Cao, RX; Cao, Ren-xian] U

Univ South China, Affiliated Hosp 1, Inst Clin Med, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Affiliated Hosp 1, Dept Endocrinol & Metab, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

S100A13;HMGA1;RNA interference;Proliferation;Invasion;Thyroid cancer

期刊：

Journal of Translational Medicine

ISSN：

1479-5876

年：

2016

卷：

期：

页码：

1-13

DOI：

10.1186/s12967-016-0824-x

基金类别：

This work is supported by projects from the National Natural Science Founda‑ tion of People’s Republic of China (Grant No. 31200573, 81172542), Hunan Provincial Natural Science Foundation of China (12JJ3116, 13JJ6051), and The Health Department of Hunan Province (B2014‑176).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Background: S100A13 and high mobility group A (HMGA1) are known to play essential roles in the carcinogenesis and progression of cancer. However, the correlation between S100A13 and HMGA1 during cancer progression is not yet well understood. In this study, we determined the effects of S100A13 on HMGA1 expression in thyroid cancer cells and examined the role of HMGA1 in thyroid cancer progression. Methods: Stable ectopic S100A13 expression TT cellular proliferation was evaluated by nude mice xenografts assays. The effect of lentivirus-mediated S...

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The association between S100A13 and HMGA1 in the modulation of thyroid cancer proliferation and invasion

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