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Novel drug targets for monkeypox: From viral to host proteins

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成果类型:
期刊论文
作者:
Zhu, Zhaozhong*;Sun, Qin;Xu, Yunhai;Niu, Youya;Yang, Fei*;...
通讯作者:
Zhu, Zhaozhong;Yang, Fei;Feng, SD
作者机构:
[Zhu, Zhaozhong; Feng, Shuidong; Sun, Qin; Yang, Fei; Yang, F] Univ South China, Sch Publ Hlth, Hengyang 421001, Hunan, Peoples R China.
[Xu, Yunhai] Hunan Prov Key Lab Geochem Proc & Resource Environ, Changsha 410116, Hunan, Peoples R China.
[Niu, Youya] Hunan Univ Med, Sch Basic Med Sci, Huaihua 418000, Hunan, Peoples R China.
通讯机构:
[Zhu, ZZ; Feng, SD ; Yang, F] U
Univ South China, Sch Publ Hlth, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
Drug;Monkeypox virus;Network;Prediction;Protein–protein interactions
期刊:
Infectious Medicine
ISSN:
2097-0684
年:
2025
卷:
4
期:
1
页码:
100165
基金类别:
Natural Science Foundation of Hunan Province, China [2021JJ30479]; PhD Scientific Research Start-up Fund of the University of South China [5524QD075]; Open Fund for Research at the Hunan Provincial Key Laboratory of Geochemical Process and Resource Environmental Effect [GRE202306G]
机构署名:
本校为第一且通讯机构
院系归属:
公共卫生学院
摘要:
Background The ongoing threat of the monkeypox virus (MPXV) underscores the need for new antiviral treatments, yet drug targets and candidate therapies are limited. The ongoing threat of the monkeypox virus (MPXV) underscores the need for new antiviral treatments, yet drug targets and candidate therapies are limited. Methods Calculating the centrality, conservation, and immunogenicity of MPXV proteins in the network to identify viral drug targets. Constructing the MIP-human protein interaction network and identifying key human proteins as poten...

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