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The Hemerocallis citrina extracts ameliorate radiation-induced ferroptosis in LO2 cells through the Nrf2-xCT/GPX4 pathway

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成果类型:
期刊论文
作者:
Zihao Zhu;Yan Wang;Zhengzheng Deng;Pengyuan Lei;Qi Liu;...
通讯作者:
Huang, B
作者机构:
[Qiancheng Qing; Huang, Bo; Bo Huang; Zihao Zhu; Jinjing Guo; Pengyuan Lei; Yan Wang; Zhengzheng Deng; Qi Liu] Univ South China, Coll Publ Hlth, Hengyang Med Sch, Hengyang, Peoples R China.
通讯机构:
[Huang, B ] U
Univ South China, Coll Publ Hlth, Hengyang Med Sch, Hengyang, Peoples R China.
语种:
英文
关键词:
Ferroptosis;Hemerocallis citrina extract;Nrf2-xCT/GPX4 pathway;Radioprotection
期刊:
针灸和草药(英文)
ISSN:
2097-0226
年:
2024
卷:
4
期:
4
页码:
513-524
基金类别:
Natural Science Foundation of Hunan Province [2021JJ30592]; Health Commission Scientific Research Project of Hunan Province [D202309037942]; Key Research Project of Education Department of Hunan Province [19A429]; National Natural Science Foundation of China [81272994]
机构署名:
本校为第一且通讯机构
院系归属:
公共卫生学院
摘要:
Background: Radiotherapy, a primary approach in cancer treatment, damages normal cells while targeting cancer cells. Therefore, it is crucial to identify drugs with minimal side effects, high reliability, and radioprotective effects to develop novel radiotherapy strategies. Hemerocallis citrina extracts (HCE), which are derived from plants with medicinal and culinary applications, possess antioxidative and anticancer properties. Methods: In this study, we investigated the radioprotective effects of HCE on LO2 cells exposed to radiation to determine whether these effects were mediated through t...

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