Green tea polyphenols protect against preglomerular arteriopathy via the jagged1/notch1 pathway

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成果类型：

期刊论文

作者：

Wang, Weixing;Tan, Hong;Liu, Hua;Peng, Huabao;Li, Xiaoyan;...

通讯作者：

He, X.

作者机构：

[Liu, Hua; Dang, Xiqiang; Wang, Weixing; He, Xiaojie; Tan, Hong; Li, Xiaoyan] Cent S Univ, Xiangya Hosp 2, Lab Childrens Kidney Dis, Childrens Med Ctr, Changsha 410000, Hunan, Peoples R China.

[Wang, Weixing] Cent S Univ, Xiangya Hosp 2, Dept Spine Surg, 139 Renmin Rd, Changsha, Hunan, Peoples R China.

[Tan, Hong] Cent S Univ, Xiangya Hosp 2, Dept Pathol, Changsha, Hunan, Peoples R China.

[Liu, Hua] Nanshan Matern & Child Healthcare Hosp Shenzhen, Dept Pediat, Shenzhen, Peoples R China.

[Peng, Huabao] Univ South China, Peoples Hosp Chenzhou 1, Dept Pediat, Chenzhou 423000, Hunan, Peoples R China.

通讯机构：

[He, Xiaojie] C

Cent S Univ, Xiangya Hosp 2, Lab Childrens Kidney Dis, Childrens Med Ctr, Changsha 410000, Hunan, Peoples R China.

语种：

英文

关键词：

Green tea polyphenols;hyperuricemia;jagged1/notch1 signaling pathway;preglomerular arteriopathy

期刊：

AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH

ISSN：

1943-8141

年：

2018

卷：

期：

页码：

3276-3290

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30500546]

机构署名：

本校为其他机构

摘要：

Preglomerular arteriopathy (PA) induced by hyperuricemia contributes to the progression of chronic kidney disease (CKD). Green tea polyphenols (GTPs) are antioxidant ingredients thought to assist in preventing hyperuricemia. However, the underlying mechanism by which GTPs affect renal function remains unclear. Both normal and remnant kidney (RK) rats were administrated oxonic acid (OX) to induce hyperuricemia. The hyperuricemia RK rats were concomitantly treated with GTPs. Hematoxlyin-eosin (H&E) and periodic acid-Schiff (PAS) staining methods ...

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Green tea polyphenols protect against preglomerular arteriopathy via the jagged1/notch1 pathway

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