SUMO3 modification by PIAS1 modulates androgen receptor cellular distribution and stability

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成果类型：

期刊论文

作者：

Yang, Nanyang;Liu, Sitong;Qin, Tian;Liu, Xintong;Watanabe, Nobumoto;...

通讯作者：

Li, Xiaomeng;Li, Jiang

作者机构：

[Liu, Sitong; Qin, Tian; Li, Xiaomeng; Yang, Nanyang] Northeast Normal Univ, Key Lab Mol Epigenet MOE, Inst Genet & Cytol, 5268 Peoples St, Changchun 130024, Jilin, Peoples R China.

[Yang, Nanyang] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Cytol & Genet, Hengyang Sch Med, Hengyang 421001, Hunan, Peoples R China.

[Liu, Sitong] Jilin Univ, Coll Life Sci, Changchun 130012, Jilin, Peoples R China.

[Li, Jiang; Liu, Xintong] Jilin Univ, Dent Hosp, Changchun 130021, Jilin, Peoples R China.

[Watanabe, Nobumoto; Liu, Xintong] RIKEN Ctr Sustainable Resource Sci, RIKEN Max Planck Joint Res Div, Bioprobe Applicat Res Unit, Wako, Saitama 3510198, Japan.

通讯机构：

[Li, Xiaomeng] N

[Li, Jiang] J

Northeast Normal Univ, Key Lab Mol Epigenet MOE, Inst Genet & Cytol, 5268 Peoples St, Changchun 130024, Jilin, Peoples R China.

Jilin Univ, Dent Hosp, Changchun 130021, Jilin, Peoples R China.

语种：

英文

关键词：

Androgen receptor;SUMO3;Sumoylation, PIAS1

期刊：

Cell Communication and Signaling

ISSN：

1478-811X

年：

2019

卷：

期：

页码：

1-16

DOI：

10.1186/s12964-019-0457-9

基金类别：

Ministry of Science and TechnologyMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT) [2016YFE0128500]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [31870758, 81602249]; Jilin Provincial Science & Technology Department [20180414057GH, 20170204009YY]; Changchun Science & Technology Department [17YJ006, 17YJ001]; Program for Introducing Talents to Universities [B07017]

机构署名：

本校为其他机构

院系归属：

药学与生物科学学院

摘要：

BACKGROUND: Abnormal reactivation of androgen receptor (AR) signaling in castration-resistant prostate cancer (CRPC) mainly results from overexpression and down-regulation of AR. Sumoylation of AR can influence its function. However, regulation of AR sumoylation by SUMO E3 ligases PIASs to modify AR distribution and stability are not well understood. METHODS: We assessed the potential effect of SUMO3 modification on AR intracellular localization by immunostaining in AR-negative prostate cancer DU145 cells, and detected the effect of PIAS1/SUMO3 overexpression on AR sumoylation related degradat...

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SUMO3 modification by PIAS1 modulates androgen receptor cellular distribution and stability

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