Immunogenicity and protective efficacy against Treponema pallidum in New Zealand rabbits immunized with plasmid DNA encoding flagellin

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zheng, Kang;Xu, Man;Xiao, Yongjian;Luo, Haodang;Xie, Yafeng;...

通讯作者：

Wu, Yimou

作者机构：

[Yu, Jian; Wu, Yimou; Zhao, Feijun; Li, Yumeng; Tan, Manyi; Luo, Haodang; Zheng, Kang; Xu, Man; Zeng, Tiebing] Univ South China, Med Coll, Inst Pathogen Biol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

[Xie, Yafeng; Xiao, Yongjian] Univ South China, Affiliated Hosp 2, Clin Lab, Hengyang 421001, Peoples R China.

[Yu, Jian] Univ South China, Med Coll, Dept Expt Zool, Hengyang 421001, Peoples R China.

通讯机构：

[Wu, Yimou] U

Univ South China, Med Coll, Inst Pathogen Biol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

语种：

英文

期刊：

Emerging Microbes & Infections

ISSN：

2222-1751

年：

2018

卷：

期：

页码：

1-10

DOI：

10.1038/s41426-018-0176-0

基金类别：

This work was supported by the National Natural Science Foundation of China (grant numbers 81471576, 81702046, and 81701577), the Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (2015-351), and the General Project in Hunan Province Science and Technology Program (grant number 2014TT2025).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Plasmid DNA encoding flagellin FlaB3 was used as a vaccination candidate for the evaluation of immunogenicity and protection against Treponema pallidum subsp. pallidum dissemination. First, intramuscular injection of the flagellin encoded by the plasmid DNA into New Zealand rabbits elicited both humoral and cellular immune responses. Total IgG production increased in response to flagellin. In addition, serum IFN-γ secretion and CD8+ cells were substantially greater in the rabbits immunized with the plasmid encoding flagellin FlaB3 than those i...

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Immunogenicity and protective efficacy against Treponema pallidum in New Zealand rabbits immunized with plasmid DNA encoding flagellin

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