Identification of potential targets for differentiation in human leukemia cells induced by diallyl disulfide

首页 > 成果 > 详情

认领

导出

下载 Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Ling, Hui;He, Jie;Tan, Hui;Yi, Lan;Liu, Fang;...

通讯作者：

Su, Qi;Jiang, Hao

作者机构：

[He, Jie; Hu, Haobin; Yi, Lan; Tan, Hui; Su, Qi; Ling, Hui; Zeng, Xi; Liu, Fang; Ji, Xiaoxia] Univ South China, Canc Res Inst, Coll Hunan Prov, Key Lab Tumor Cellular & Mol Pathol, 28 Western Changshen Rd, Hengyang 421001, Hunan, Peoples R China.

[He, Jie; Hu, Haobin; Tan, Hui; Su, Qi; Ling, Hui; Zeng, Xi; Liu, Fang] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hunan Prov Educ Dept, Hengyang 421001, Hunan, Peoples R China.

[Ai, Xiaohong; Jiang, Hao; Wu, Youhua] Univ South China, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Su, Qi; Jiang, Hao] U

Univ South China, Canc Res Inst, Coll Hunan Prov, Key Lab Tumor Cellular & Mol Pathol, 28 Western Changshen Rd, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

diallyl disulfide;leukemia;potential targets;proteomics;differentiation

期刊：

INTERNATIONAL JOURNAL OF ONCOLOGY

ISSN：

1019-6439

年：

2017

卷：

期：

页码：

697-707

DOI：

10.3892/ijo.2017.3839

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81100375, 31201027, 81400117]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2015JJ4042]; Patency Foundation of Innovation Platform of Hunan Provincial University of China [11K057]; construction program of the key discipline in Hunan Province, China (Basic Medicine Sciences in University of South China)

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Diallyl disulfide (DADS) is a primary component of garlic, which has chemopreventive potential. We previously found that moderate doses (15-120 microM) of DADS induced apoptosis and G2/M phase cell cycle arrest. In this study, we observed the effect of low doses (8 microM) of DADS on human leukemia HL-60 cells. We found that DADS could inhibit proliferation, migration and invasion in HL-60 cells, and arrested cells at G0/G1 stage. Then, cell differentiation was displayed by morphologic observation, NBT reduction activity and CD11b evaluation of cytometric flow. It showed that DADS induced diff...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Identification of potential targets for differentiation in human leukemia cells induced by diallyl disulfide

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问