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Identification of potential targets for differentiation in human leukemia cells induced by diallyl disulfide

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成果类型:
期刊论文
作者:
Ling, Hui;He, Jie;Tan, Hui;Yi, Lan;Liu, Fang;...
通讯作者:
Su, Qi;Jiang, Hao
作者机构:
[He, Jie; Hu, Haobin; Yi, Lan; Tan, Hui; Su, Qi; Ling, Hui; Zeng, Xi; Liu, Fang; Ji, Xiaoxia] Univ South China, Canc Res Inst, Coll Hunan Prov, Key Lab Tumor Cellular & Mol Pathol, 28 Western Changshen Rd, Hengyang 421001, Hunan, Peoples R China.
[He, Jie; Hu, Haobin; Tan, Hui; Su, Qi; Ling, Hui; Zeng, Xi; Liu, Fang] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hunan Prov Educ Dept, Hengyang 421001, Hunan, Peoples R China.
[Ai, Xiaohong; Jiang, Hao; Wu, Youhua] Univ South China, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Su, Qi; Jiang, Hao] U
Univ South China, Canc Res Inst, Coll Hunan Prov, Key Lab Tumor Cellular & Mol Pathol, 28 Western Changshen Rd, Hengyang 421001, Hunan, Peoples R China.
Univ South China, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
calreticulin;CD11b antigen;cofilin 1;cycline;diallyl disulfide;protein deglycase DJ-1;Rho guanine nucleotide dissociation inhibitor 2;allyl compound;CD11b antigen;diallyl disulfide;disulfide;ITGAM protein, human;proteome;animal experiment;animal model;animal tissue;antigen expression;antineoplastic activity;Article;carcinogenesis;cell differentiation;controlled study;disease activity;down regulation;drug cytotoxicity;drug effect;drug mechanism;flow cytometry;G1 phase cell cycle checkpoint;human;human cell;in vivo study;leukemia;leukemia cell line;mass spectrometry;molecular pathology;mouse;nonhuman;protein expression;reverse transcription polymerase chain reaction;tumor xenograft;upregulation;Western blotting;animal;cell cycle checkpoint;cell motion;cell proliferation;dose response;drug effects;drug screening;gene expression regulation;genetics;HL-60 cell line;leukemia;metabolism;Allyl Compounds;Animals;Antigens, CD11b;Cell Cycle Checkpoints;Cell Differentiation;Cell Movement;Cell Proliferation;Disulfides;Dose-Response Relationship, Drug;Gene Expression Regulation, Neoplastic;HL-60 Cells;Humans;Leukemia;Mice;Proteome;Xenograft Model Antitumor Assays
期刊:
INTERNATIONAL JOURNAL OF ONCOLOGY
ISSN:
1019-6439
年:
2017
卷:
50
期:
2
页码:
697-707
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81100375, 31201027, 81400117]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2015JJ4042]; Patency Foundation of Innovation Platform of Hunan Provincial University of China [11K057]; construction program of the key discipline in Hunan Province, China (Basic Medicine Sciences in University of South China)
机构署名:
本校为第一且通讯机构
院系归属:
医学院
药学与生物科学学院
摘要:
Diallyl disulfide (DADS) is a primary component of garlic, which has chemopreventive potential. We previously found that moderate doses (15-120 μM) of DADS induced apoptosis and G2/M phase cell cycle arrest. In this study, we observed the effect of low doses (8 μM) of DADS on human leukemia HL-60 cells. We found that DADS could inhibit proliferation, migration and invasion in HL-60 cells, and arrested cells at G0/G1 stage. Then, cell differentiation was displayed by morphologic observation, NBT reduction activity and CD11b evaluation of cytom...

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