期刊论文

Jiang, Zhi-Sheng;Zheng, Xi-Long

英文

JOURNAL OF CELLULAR PHYSIOLOGY

0021-9541

2019

234

3

2345-2355

10.1002/jcp.27254

This study was supported by the grants from the National Natural Science Foundation of China (81770454), the Educational Department of Hunan Province Fund for Distinguished Young Scholars (16B228). National Natural Science Foundation of China, the Educational Department of Hunan Province Fund for Distinguished Young Scholars, Grant/Award Numbers: 81770454, 16B228

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Proprotein convertase subtilisin/kexin 9 (PCSK9) is the ninth member of the secretory serine protease family. It binds to low-density lipoprotein receptor (LDLR) for endocytosis and lysosome degradation in the liver, resulting in an increasing in circulating LDL-cholesterol (LDL-c) level. Since a PCSK9 induced increase in plasma LDL-c contributes to atherosclerosis, PCSK9 inhibition has become a new strategy in preventing and treating atherosclerosis. However, in addition to the effect of PCSK9 on elevating blood LDL-c levels, accumulating evid...