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Fabrication of nanospheres and vesicles as drug carriers by self-assembly of alginate

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成果类型:
期刊论文
作者:
Yu, Cui-Yun;Jia, Li-Hui;Yin, Bo-Cheng;Zhang, Xian-Zheng;Cheng, Si-Xue*;Zhuo, Ren-Xi
通讯作者:
Cheng, Si-Xue
作者机构:
[Jia, Li-Hui; Yin, Bo-Cheng; Zhuo, Ren-Xi; Cheng, Si-Xue; Yu, Cui-Yun; Zhang, Xian-Zheng] Wuhan Univ, Dept Chem, Minist Educ, Key Lab Biomed Polymers, Wuhan 430072, Peoples R China.
[Yu, Cui-Yun] Univ S China, Sch Life Sci & Technol, Dept Pharm, Hengyang 421001, Peoples R China.
通讯机构:
[Cheng, Si-Xue] Wuhan Univ, Dept Chem, Minist Educ, Key Lab Biomed Polymers, Wuhan 430072, Peoples R China.
语种:
英文
期刊:
Journal of Physical Chemistry C
ISSN:
1932-7447
年:
2008
卷:
112
期:
43
页码:
16774-16778
基金类别:
National Natural Science Foundation of China [20774070, 50633020]; Ministry of Science and Technology of China [2005CB623903]
机构署名:
本校为其他机构
院系归属:
药学与生物科学学院
摘要:
A new method was developed to fabricate nanospheres and vesicles as drug carriers. The drug-loaded nanospheres and vesicles were prepared by self-assembly of alginate in aqueous media containing Ca<sup>2+</sup> and CO<inf>3</inf><sup>2-</sup> ions under very mild conditions. The preparation method did not involve any organic solvent and surfactant and could offer good control over the morphology and the size of self-assemblies. Through adjusting the preparation conditions, nanosized drug-delivery systems with different shapes, that is, nanospheres and vesicles, could be obtained. The morphologies of the drug-delivery systems were observed by transmission electron microscopy (TEM). 5-Fluorouracil (5-FU), an anticancer drug, was encapsulated in the nanospheres and vesicles, and in vitro drug release behavior was investigated. The effect of drug-loading content on the release was studied. The release of 5-FU could be effectively sustained from both drug-loaded nanospheres and vesicles because the presence of CaCO<inf>3</inf> in the nanospheres/vesicles could reduce the permeability of the entrapped drug for the alginate-based self-assemblies. &copy;2008 American Chemical Society.

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