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Anticancer activity of oleanolic acid and its derivatives modified at A-ring and C-28 position

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成果类型:
期刊论文
作者:
Gao, Cong-Xi;Tang, Cai-Hong;Wu, Ting-Juan;Hu, Yue;Peng, Ya-Ling;...
通讯作者:
Ze-Hua Yang<&wdkj&>Xing Zheng
作者机构:
[Chen, Hong-Fei; Yang, Ze-Hua; Gao, Cong-Xi; Wu, Ting-Juan; Peng, Ya-Ling; Liu, Qian-Wen; Tang, Cai-Hong; Hu, Yue; Liu, Mei-Ling; Zheng, Xing] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hunan Prov Key Lab Tumor Microenvironm Respons Dr, Grp Lead Compound,Dept Pharm,Hengyang Med Sch, Hengyang 421001, Peoples R China.
[Gao, Cong-Xi] Kunming Med Univ, Sch Pharm, Kunming 650500, Yunnan, Peoples R China.
[Gao, Cong-Xi] Kunming Med Univ, Yunnan Key Lab Nat Med Pharmacol, Kunming 650500, Yunnan, Peoples R China.
通讯机构:
[Ze-Hua Yang; Xing Zheng] G
Group of Lead Compound, Department of Pharmacy, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang Medicinal School, University of South China, Hengyang421001, China<&wdkj&>Group of Lead Compound, Department of Pharmacy, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang Medicinal School, University of South China, Hengyang421001, China
语种:
英文
关键词:
Oleanolic acid derivatives;A ring modification;anticancer activity;C-28 site modification;mechanism of action
期刊:
亚洲天然物产研究(英文版)
ISSN:
1028-6020
年:
2023
卷:
25
期:
6
页码:
581-594
基金类别:
The authors thank the Research Foundation of Education Bureau of Hunan Province (No. 19K079), Hunan Provincial Hengyang Joint Fund (2020JJ6052), Laboratory of Tea and Health of Hengyang (202150083704), University of South China Innovation Foundation for undergraduate (Nos. 210XCX360 and S202010555176) for financial support.
机构署名:
本校为第一机构
院系归属:
药学与生物科学学院
摘要:
Oleanolic acid (OA) is a five-ring triterpenoid compound, which is widely present in plants. Due to a wide range of pharmacological activities, oleanolic acid has attracted more and more attention. However, oleanolic acid is insoluble in water and has low bioavailability, which limits its clinical application. In this review, we focus on summarizing the anti-cancer activity and mechanism of the A ring or C-28 carboxyl modified derivatives of OA since 2015, to determine the strength of its anti-cancer effectiveness and evalu...

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